ID L5KSX4_PTEAL Unreviewed; 943 AA.
AC L5KSX4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative G-protein coupled receptor 113 {ECO:0000313|EMBL:ELK14046.1};
GN ORFNames=PAL_GLEAN10020232 {ECO:0000313|EMBL:ELK14046.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14046.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; KB030580; ELK14046.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KSX4; -.
DR STRING; 9402.L5KSX4; -.
DR eggNOG; KOG4193; Eukaryota.
DR InParanoid; L5KSX4; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15253; 7tmB2_GPR113; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR PANTHER; PTHR45813:SF2; ADHESION G-PROTEIN COUPLED RECEPTOR F3; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK14046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..943
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969526"
FT TRANSMEM 654..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 312..349
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 648..902
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 943 AA; 101155 MW; DCBE52D6BDE51BBE CRC64;
MVCWAAPVLL LAVTVSLVGS PVAQASQSVS KTGVRTLGKA AEGTIGSSGC ERQQECNVEN
NGFTSCACLS GYQWNASVCA SHHPCRPRFK HQPCSCLVIG PTEAGYCQLL PPVPGTLSLN
TSLQMPGDTL NLTLLTSHET ANLNWFLQRT GSPRPVLLQP GTHVSLTSSQ GQAVLSIFNI
SHKWEGVYIC CFEAQGFRWE LYQVVRVPLQ VTDVAQLPDQ LSISCATSPG FQLSCCFPRT
HLSYTASWSP IEGSKASLFD KPGDQCLVLT VQRCPTADTT YTCDLESPGL TPLRVPVFVT
IIQGGDTTCP EDSSAIAWNV TKAGHVAQAP CPVNRMGVVK RTCGPDGTWR PSRSSCTDVG
LLALLQRAQL LGAGQGRPAD EVPRILAQLL ERVVLVNSPS DLLALLGTMT FLAKTVADAR
IQLHRRALEA LLKTTDKVLD LDASSLWTPA QAQKPSAGSN LLRAVETLAC SLSPQARPFS
FSLPNVQLQT QLRVPAFSAD YKVSFSTQPP VQVQIPRRSL TPLGHNGTNV IITSLVLRKL
DRLLPSNYGQ GLGAPLYTTP GLVLAISIMA GGQTFGQGEV IMDFGDTNST LHCVFWDHDL
FQGSGGWSDE GCQVQAASAS PTTRCICRHL TAFSILMSRH AVPKPPALEL LSQMGLVASI
LALLVCLGVY RLVWRVVTRN KVAYLRHAAL LNIALCLLAA DTCFLGAPLL PPGPQSPLCL
AAAFLCHFLY LASFFWMLAQ ALMLAHQLLF VFHQLSKRQA LSLMVVLGYL CPMGFAGVAL
VLFLPQGQYL GAGACWLDGK GGALYTFVGP VLAIVGVNGL VLAVAVLKLL RPSLSEGPQL
EKCQTLLGVI KALLVLTPIF GLTWGLGLAT LLEDVSIVPH YIFTILNTSQ GVFILLFGCL
MDKKVQEALL KRFCHAPTPN STISLATNET HILEHSKGSE NAG
//
