ID L5KTE5_PTEAL Unreviewed; 948 AA.
AC L5KTE5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Zinc finger protein 268 {ECO:0000313|EMBL:ELK14216.1};
GN ORFNames=PAL_GLEAN10008678 {ECO:0000313|EMBL:ELK14216.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14216.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; KB030576; ELK14216.1; -; Genomic_DNA.
DR RefSeq; XP_015443395.1; XM_015587909.1.
DR AlphaFoldDB; L5KTE5; -.
DR STRING; 9402.L5KTE5; -.
DR GeneID; 102889398; -.
DR InParanoid; L5KTE5; -.
DR OrthoDB; 4637982at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 23.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF398; ZINC FINGER PROTEIN 715; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 23.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 12.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 23.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 81..152
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 277..304
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 305..332
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 333..360
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 361..388
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 389..416
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 417..444
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 445..472
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 473..500
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 501..528
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 529..556
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 557..584
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 585..612
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 613..640
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 641..668
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 669..696
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 697..724
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 725..752
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 753..780
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 781..808
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 809..836
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 837..864
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 865..892
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 893..920
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 109424 MW; EABC822751B4C07F CRC64;
MATRVRTAAI WVPPLQEQDG PCRRIRKLQG KEFSIDQGTP DQRRLPRGPQ QRHKNHKTEQ
VLEWLLISQE QLKTTRSQGL LSFTDVFVHF TWEEWRLLDA AQKHLYRSVM LENYGNLVSL
GYQHTKPDVI FKLEQEEELW MRQAQVPSQS PLDRVWEVGN HMEWHQENQG KLGNMAKCYE
RSAFGKLCLL TTNYVSSRQK LYKWGTREKS LKYNIDFNIN YAGKNPNRFH AQRESFLRSK
HEQTVIGIKY CESNESRKTN KNSQLICQQM YIGGKPFECS YCGKVFSSKS YLIIHQRTHT
GEKLHECSEC RKTFRFNSQL VTHQRNHTGE DHYECCECGK VFRRKDQLIS HQRTHSGRKP
YGCNECGKAF GLKSQLIIHQ RIHTGEKPYE CSDCRKAFNT KSNLLVHQRT HTGEKPYGCN
ECGKAFTFKS QLIVHQGLHT GVKPYGCIQC GKAFSLKSQL IVHQRSHTGM KPYVCDECDK
AFRSKSYLII HMRTHTGEKL HECNECGKSF SFNSQLIIHQ RIHTGESPYE CHECGKAFSR
KYQLISHQRT HAGEKPYECS DCAKTFGLKS QLIIHQRIHT GEKPYECSDC RKAFNTKSNL
LVHQRTHTGE KPYGCSECGK AFTFKSQLIV HQGTHTGVKP YGCNQCGKAF SLKSQLIVHQ
RSHTGVKPYG CSECGKAFRS KSYLIIHMRA HTGEKPHECN ECGKSFSFNS QLLVHQRIHT
GENPYECSEC GKAFNRKDQL VSHQRTHAGE KPYGCSECGK AFSSKSYLII HMRTHSGEKP
YECNKCGKAF IWKSLLIVHE RTHSGENPYK CSQCEKSFSG KLRLVVHQRM HAREKPFECS
ECEKAFIRKS QLVVHHRTHS GEKPYGCNEC GKTFSQKSIL SAHQRTHTGE KPCKCTECGK
AFCWKSQLIM HQRTHAGEKH FDELNVRNFL SKVNAQEIPA NSCRRETL
//
