ID L5KUA8_PTEAL Unreviewed; 650 AA.
AC L5KUA8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Protein spire like protein 1 {ECO:0000313|EMBL:ELK15044.1};
GN ORFNames=PAL_GLEAN10003852 {ECO:0000313|EMBL:ELK15044.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15044.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm,
CC cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the spire family.
CC {ECO:0000256|ARBA:ARBA00010956}.
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DR EMBL; KB030553; ELK15044.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KUA8; -.
DR STRING; 9402.L5KUA8; -.
DR InParanoid; L5KUA8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR GO; GO:0022607; P:cellular component assembly; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd15767; FYVE_SPIR1; 1.
DR CDD; cd22078; WH2_Spire1_r2-like; 1.
DR CDD; cd22080; WH2_Spire1_r4; 1.
DR CDD; cd22065; WH2_Spire_1-2_r1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029905; Spir-1_FYVE-rel_dom.
DR InterPro; IPR029901; Spire.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR PANTHER; PTHR21345:SF8; PROTEIN SPIRE HOMOLOG 1; 1.
DR PANTHER; PTHR21345; SPIRE; 1.
DR Pfam; PF16474; KIND; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51377; KIND; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..73
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 74526 MW; 8448A026EF8C3E1A CRC64;
MANTVEADGS NDEGYEAAEE GLEDEDDEKR KISAIRSYRD VMKLCAAHLP TESEAPNHYQ
AVCRALFAET MELHTFLTKI KSAKENLKKI QEMEKSDESH TDLEELKNAD WARFWVQVMR
DLRNGVKLKK VQERQYNPLP IEYQLTPYEM LMDDIRSKRY TLRKVMVNGD IPPRLKKSAH
EIILDFIRSR PPLNPASARK LKPTPPRPRS LHERILEEIK AERKLRPVSP EEIRHSRLAV
RPLSMSYSFD LSDVTTPQSP KNIVEASMLN GGLTSQTKEN GLRVAQQVPA QRKKLLKAPT
LAELDSSDSE VPRLASETIL TAFSDITTLG TKQQWSSASS ESDLIIARIW LRVTGQDVEP
EKEETLHKSA SSSSMSPSFL EDPLLEAVSM RKTPPKFLPI SSTPQPERRQ PPQRRHSIEK
ETPTNVRQFL PPSKQSSRSL EEFCYPVECL ALTVEEVMHI RQVLVKAELE KYQQYKDVYT
ALKKGKLCFC CRTRRFSFFT WSYTCQFCKR PVCSQCCKKM RLPSKPYSTL PIFSLGPSAL
QRGESCMRPE KPSTGHHRPL RSIARFSSKS KSVDKPDEEL QFPKELMEDW STMEVCVDCK
KFISEIISSS RRSLVLANKR ARLKRKTQSF YMSSPGPSEY CPSERTINEI
//
