ID L5KUG3_PTEAL Unreviewed; 686 AA.
AC L5KUG3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Hepatocyte growth factor-like protein {ECO:0000313|EMBL:ELK15104.1};
GN ORFNames=PAL_GLEAN10009191 {ECO:0000313|EMBL:ELK15104.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15104.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC {ECO:0000256|PIRNR:PIRNR001152}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; KB030552; ELK15104.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KUG3; -.
DR STRING; 9402.L5KUG3; -.
DR InParanoid; L5KUG3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00108; KR; 3.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR024174; HGF/MST1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24261:SF12; HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 4.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001152; HGF_MST1; 3.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 4.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00021; KRINGLE_1; 3.
DR PROSITE; PS50070; KRINGLE_2; 4.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Serine protease homolog {ECO:0000256|PIRNR:PIRNR001152}.
FT DOMAIN 65..149
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 153..230
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 234..312
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 329..365
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 373..452
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 488..684
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 235..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 256..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 284..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 336..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 686 AA; 77700 MW; 00E28437A7D66D89 CRC64;
MTAAPLTPEQ VQGRSDMVIR VMGKPSGYPL CQALRTREGV SSRPILLFKP GASSLFYWAW
RRQRSPLNDF QVLRGAELQH LLHARRPEPW QEDVADAEEC AGRCKPLLDC RAFHYNVSSH
GCQLLPWTQN SPHTQLQRSG RCDLFQKKDY VRTCIVDNGV EYRGTVAITT GGLPCQRWSH
RFPNDHRYLP TLRNGLENNF CRNPDGDAGG PWCYTTDPAV RFQSCGIKSC REATCFWCNG
EDYRGAVDRT ESGRECQRWD LQRPHPHPFE PGKFLDKHLD DNYCRNPDGS ERPWCYTTDP
QVEREFCDLP RCGRTRGPGL GDAWKMWGAD LRENFCRNPD GSEAPWCFTS RPGMRVAFCY
QIRRCTDDVR PKECYHGAGE KYRGSISKTR KGIPCQRWSA ETPHKSLFTP ISAPHAQLEE
NFCRNPDGDS HGPWCYTTDP GTPFDYCALR RCDDDHPPSI LEPPDKVLFE KCGKRVPHLD
QHGSKLRVVG GQPGNSPWTV SLRNRHMSLL GYEVWLGTMF QNPQPGEPGL QRVSVAKMVC
GPSGSQLALL KLERPVTLNQ YVALICLPPE RYVVPPETKC EIAGWGESKA NSVLNVALLN
VISNQECNIK HRGRVRESEM CTKALLAPAG ACEGDYGGPL ACFTHDCWVL EGIIIPNRVC
ARPRWPAVFT RVSVFVDWIH KVMRLS
//
