ID L5KV09_PTEAL Unreviewed; 661 AA.
AC L5KV09;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Melanocyte protein Pmel 17 {ECO:0000313|EMBL:ELK15262.1};
GN ORFNames=PAL_GLEAN10004803 {ECO:0000313|EMBL:ELK15262.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15262.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB030539; ELK15262.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KV09; -.
DR STRING; 9402.L5KV09; -.
DR eggNOG; ENOG502QV5K; Eukaryota.
DR InParanoid; L5KV09; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..661
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969474"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..292
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 424..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 70614 MW; 2FE35D5D97EEE556 CRC64;
MDLVQRKCLL HVAVMGALLA VGATEGPRDW RWHGISRQLR TKAWNRELYP EWTEIQRPDC
WRGGQVSLKV SNDGPTLVGA NASFSISLHF PESQKVMSDG QVIWNNNTII NGSQVWEGQP
VYPQEPDDAC IFPDGEACPS GPWFQRRRFV YVWKTWGQYW QVLGGPVSGL SIETGTAELG
IHTMEVTVYH RRGSQSYVPL AHSRSAFTIT DQVPFSVSVS QLQALDGGNK RFLRNQPLIF
ALQLHDPSGY LSGADLSYTW DFGDSTGTLI SRALVVTHTY LESGPITARA VLQAAIPLTS
CGSSPVPGTT DGYVPTAEAP GTTAGLVPTA EVVGTTPGQV PTAEPSGTTA VQVPTTEVIG
TVSVQVPTEE GIGTTPEQVP TSEIIGTTLA EMPTAEAIGT PEVSTAEPSE TTVAQVTTTE
LVETTAGEVP TPEPESPDVS LSMPTEGITG SQSPLLDSTA TLNLVKRQVP SDCVLYRYGS
FSLTLDIVQG IENAEILQAV PSSEGDAFEL TVSCQGGLPE EACMDISSPG CQPPAQRLCQ
PVLPSPACQL VLHQELTGGS GTYCLNVSLA DANSLAMVST QLVMPGQEAG LGQAPLLMGI
LLALMAMVLA SLIYRRRLMK QGSSNPLSQL PHSSTHWLRL PRVFHSYSIG ENSPLLSGQQ
V
//
