ID L5KVA3_PTEAL Unreviewed; 980 AA.
AC L5KVA3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Echinoderm microtubule-associated protein-like 4 {ECO:0000313|EMBL:ELK14753.1};
GN ORFNames=PAL_GLEAN10021311 {ECO:0000313|EMBL:ELK14753.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14753.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; KB030567; ELK14753.1; -; Genomic_DNA.
DR RefSeq; XP_006909707.1; XM_006909645.2.
DR AlphaFoldDB; L5KVA3; -.
DR STRING; 9402.L5KVA3; -.
DR GeneID; 102879824; -.
DR CTD; 27436; -.
DR eggNOG; KOG2106; Eukaryota.
DR InParanoid; L5KVA3; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR CDD; cd21950; TD_EMAP4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF11; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 227..295
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 504..536
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 587..619
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 716..757
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 829..863
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 107..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..51
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 110..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 109234 MW; 0A3520EF5B01048C CRC64;
MDGFAGSLDD SISAASTSDV QDRLSALELR VQQQEDEITV LKAALADVLR RLAISEDHVA
SVKKSVPNKG QPGIREAISM SCITNGSGAN RKPSHTTSVS IARKETLSSA AKSGTEKKKE
KPQGQREKRE ESHSNDQSPQ IRASPSPQPS SQPLQIHRQT QESKNSTPTK SIKRPTAEKS
HNSWENSDDS RNKLLKAVST SKLISRVIKN TDKHKDVIIN QEGEYVKMFM RGRPITMFIP
SDVDNYDDIR TELPPEKLKL EWAYGYRGKD CRANVYLLPT GEIVYFIASV VVLFNYEERT
QRHYLGHTDC VKCLAVHPDK IRIATGQIAG VDKDGRPLQP HVRVWDSVSL ATLQIIGLGT
FERGVGCLDF SKADSGVHLC VIDDSNEHML TVWDWQKKSK GAEIKTTNEV VLAVEFHPTD
ANIIITCGKS HIFFWTWSGN SLTRKQGIFG KYEKPKFVQC LAFMGNGDVL TGDSGGVILI
WSKTTVEPTP GKGPKGVYQI SKQIKAHDGS VFTLCQMRNG MLLTGGGKDR KVILWDHDLN
PEREIEVPDQ YGTIRAVAEG KADQFLVGTS RNFILRGTFN DGFQIEVQGH TDELWGLATH
PFKDLLLTCA QDRQVCMWNS VEHRLEWTRL VDEPGHCADF HPSGTVVAIG THSGRWFVLD
AETRDLVSIH TDGNEQLSVM RYSVDGTFLA VGSHDNFIYL YVVSENGRKY SRYGKCTGHS
SYITHLDWSP DNKYIMSNSG DYEILYWDIP SGCKLIRNRS DCKDIDWTTY TCVLGFQVFG
VWPEGSDGTD INALVRSHNR KVIAVADDFC KVHLFQYPCS KAKAPSHKYS AHSSHVTNVS
FTHNDSHLIS TGGKDMSIIQ WKLVEKLSLP QNEIVADTSL TKAPISSIEN VMQSNTPTPP
PSQPLNETAE EESRISNSPT LLENSLEQTM EPSEDHSEEQ SEGGSEDLGE PVYEEPSSEM
REEQSETTLT EDQQDPSPLS
//
