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Database: UniProt
Entry: L5KWJ0_PTEAL
LinkDB: L5KWJ0_PTEAL
Original site: L5KWJ0_PTEAL 
ID   L5KWJ0_PTEAL            Unreviewed;      2722 AA.
AC   L5KWJ0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   28-FEB-2018, entry version 25.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|EMBL:ELK15178.1};
GN   ORFNames=PAL_GLEAN10009282 {ECO:0000313|EMBL:ELK15178.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15178.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB030552; ELK15178.1; -; Genomic_DNA.
DR   InParanoid; L5KWJ0; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELK15178.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2247   2269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2281   2299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2368   2393       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2413   2435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2543   2566       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    104       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      111    161       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    311       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      317    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1536   1556       {ECO:0000256|SAM:Coils}.
FT   COILED     2660   2701       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2722 AA;  309573 MW;  20903143203124EB CRC64;
     MNRYSAQKQF WKAAKPGANS TTDAVLLNKL HHAADLEKKQ NETENRKLLG TVIQYGNVIQ
     LLHLKSNKYL TVNKRLPALL EKNAMRVTLD EAGNEGSWFY IQPFYKLRSI GDSVVIGDKV
     VLNPVNAGQP LHASSHQLVD NPGCNEVNSV NCNTSWKIVL FMKWSDNKDD ILKGGDVVRL
     FHAEQEKFLT CDEHRKKQHV FLRTTGRQSA TSATSSKALW EVEVVQHDPC RGGAGYWNSL
     FRFKHLATGH YLAAEVDPDF EEECLEFQPP ADPDQDASRS RLRNAQEKML YSLVSVPEGS
     DISSIFELDP TTLRGGDSLV PRNSYVRLRH LCTNTWVHST NIPIDKEEEK PVMLKIGTSP
     VKEDKEAFAI VPVSPAEVRD LDFANDASKV LGSIAGKLEK GTITQNERRS VTKLLEDLVY
     FVTGGTNSGQ DVLEVVFSKP NRERQKLMRE QNILKQIFKL LQAPFTDCGD GPMLRLEELG
     DQRHAPFRHI CRLCYRVLRH SQQDYRKNQE YIAKQFGFMQ KQIGYDVLAE DTITALLHNN
     RKLLEKHITA AEIDTFVSLV RKNREPRFLD YLSDLCVSTN KSIPVTQELI CKAVLNPTNA
     DILIETKLVL SRFEFEGVAT GESALEAGED EEEVWLFWRA GHKEVRSKSV RELAQDAKEG
     QKEDRDVLGY YRYQLNLFAR MCLDRQYLAI NEISGQLDVD LILRCMSDEN LPYDLRASFC
     RLMLHMHVDR DPQEQVTPVK YARLWSEIPS EIAIDDYDSS GASKDEMKQR FAQTMGFVEE
     YLRDVVCQRF PFSDKEKNKL TFEVVNLARN LIYFGFYNFS DLLRLTKILL AILDCVHVTT
     IFPITKMAKG DENKGSNVMR SIHGVGELMT QVVLRGGAFL PVAPMAAAPE GTVKQAEPEK
     EDIMVMDTKL KIIEILQFIL NVRLDYRISC LLCIFKREFD ESNSQTSEAS SGSSSQEGPS
     SVPGALDFEH IEEQAEGIFG GRKVYFHEEN TPLDLDDHGG RTFLRVLLHL TMHDYPPLVS
     GALQLLFRHF SQRQEVLQAF KQVQLLVTSQ DVDNYKQIKQ DLDQLRSIVE KSELWVYKGQ
     GPDEAMEGPS GENEHKKTED GNNKSQKHES TSSYNYRVVK EILVRLSKLC VQESASVRKS
     RKQQQRLLRN MSAHAVVLEL LQIPYEKAED TKMQEIMRLA HEFLQNFCAG NQQNQALLHK
     HTNLFLNPGI LEAVTMQHIF MNNFQLCSEI NERVVQHFVH CIETHGRNVQ YIKFLQTIVK
     AEGKFIKKCQ DMVMAELVNS GEDVLVFYND RASFQTLIQM MRSERDRMDE NSPLMYHIHL
     VELLAVCTEG KNVYTEIKCN SLLPLDDIVR VVTHEDCIPE VKIAYINFLN HCYVDTEVEM
     KEIYTSNHMW KLFENFLVDI CRACNNTSDR KHADSVLEKY VTEIVMSIVT TFFSSPFSDQ
     STTLQTRQPV FVQLLQGVFR VYHCNWLVPS QKASVESCIR VLSDVAKSRA IAIPVDLDSQ
     VNNLFLKSHN IVQKTAMSWR LSARNAARRD SVLAASRDYR NIIERLQDIV SALEDRLRPL
     VQAELSVLVD VLHRPELLFP ENTDARRKCE SGGFICKLIK HTKQLLEENE EKLCIKVLQT
     LREMMTKDRG YGEKGEALRQ ILVNRYYGNI RPSGRRESLT SFGNGPLSPG GPSKPGGGVS
     SGGGWGGCSS LGNRPPEWHP RPPCPVTDEE AEATVSSVTW ASPPSSAVTP PRRQDVTPIS
     EPPAALHEHR HGNGPDSDHS FFCRLTEDKK SEKFFKVFYD RMKAAQQEIK ATVTVNTSDL
     GNKKKDDEAD RDAPSRRKAK EPSTQITEEV RDQLLEASAA TRKAFTTFRR EADPDDHYQP
     GEGTQAAADK TKDDLEMSAV VTIMQPILRF LQLLCENHNR DLQERELRKS ICTQGPRPAS
     SGPCVKTERP PPSSWFCAAH VVVHGTRSSH RGSGFRLWRL MAAGTRQWST RPVDVEKCVP
     SLPERNFLRC QNNKTNYNLV CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL
     TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK RMDLNNASKL LLAIMESRHD
     SENAERILYN MRPKELXXXX XXXXXXXXXX XXXXLARHNK ELQSMLKPGG QVDGDAALGF
     YAKHTAQIEI VRQDRTMEQI VFPVPSICEF LTKESKLRIY YTTERDEQGS KINDFFLRSE
     DLFNEMNWQK KLRAQPVLYW CARNMSFWSS ISFNLAVLMN LLVAFFYPFR GVRGGTLEPH
     WSGLLWTAML VSLAIVIALP KPHGVRALIA STILRLIFSV GLQPTLFLLG AFNVCNKIIF
     LMSFVGNCGT FTRGYRAMVL DVEFLYHLLY LLICAMGLFV HEFFYSLLLF DLVYREETLL
     NVIKSVTRNG RSIILTAVLA LILVYLFSIV GYLFFKDDFI LEVDRLPNDT VLPEAGESLA
     SEFLHSDVCR VKTGESCSPT APQEELPPAE ETEQDQEHTC ETLLMCIVTV LSHGLRSGGG
     VGDVLRKPSK EEPLFAARVI YDLLFFFMVI IIVLNLIFGV IIDTFADLRS EKQKKEEILK
     TTCFICGLER DKFDNKTVTF EEHIQEEHNM WHYLCFIVLV KVKDSTEYTG PESYVAEMIK
     ERNLDWFPRM RAMSLVSSDS EGEQNELRNL QEKLESTMKL VTNLSGQLSE LKDQMTEQRK
     QKQRIGLLGH PPHMNANPQQ PA
//
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