ID L5KX92_PTEAL Unreviewed; 851 AA.
AC L5KX92;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Breakpoint cluster region protein {ECO:0000313|EMBL:ELK15621.1};
GN ORFNames=PAL_GLEAN10010892 {ECO:0000313|EMBL:ELK15621.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15621.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030536; ELK15621.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KX92; -.
DR STRING; 9402.L5KX92; -.
DR eggNOG; KOG4269; Eukaryota.
DR InParanoid; L5KX92; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF3; BREAKPOINT CLUSTER REGION PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 122..315
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 332..490
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 634..828
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 41..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 408..448
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 96079 MW; FB60454B3EF2CFDB CRC64;
MEGLAFLVGQ LWASEMGGVG PVFRALVGFG VGQMDVITLP GLPRTHRSPT DTSFGTPPGY
GSATDRTEEQ RRHQDGLPYI DDSPSSSPHL GSKGRGSRDA MASGALESTK ASELDLEKGL
EMRKWVLSGI LASEETYLSH LEALLLPMKP LKAAATTSQP VLTSQQIETI FFKVPELYEI
HKEFYDGLFP RVQQWSHQQR VGDLFQKLAS QLGVYRAFVD NYGVAMETAE KCCQANAQFA
EISENLRARS NKDAKDQTTK NSLETLLYKP VDRVTRSTLV LHDLLKHTPS SHPDHPLLQD
ALRISQNFLS GINEEITPRR QSMTVKKGEH RQLLKDSFMV ELVEGARKLR HVFLFTDLLL
CTKLKKQSGG KTQQYDCKWY IPLTDLSFQT VDESEAAPNI PLVLDEELDA MKIKISQIKS
DIQREKRANK ASKAIERLKK KLSEQESLLL LMSPSMAFRV HNRNGKSYTF LISSDYERAE
WRENIREQQK KCFKSFSLTS VELQMLTNSC VKLQTVHSIP LTINKEDDES PGLYGFLNVI
VHSATGFKQS SNLYCTLEVD SFGYFVNKAK TRVYRDTTEP NWNELDPQAL QDRDWQRTVI
AMNGIEVKLS VKFTSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER
RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF
TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKETVNKMSL
HNLATVFGPT LLRPSEKESK LPANPSQPIS MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS
KRQSILFSTE V
//
