ID L5KYC8_PTEAL Unreviewed; 255 AA.
AC L5KYC8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Interferon alpha-1 {ECO:0000313|EMBL:ELK15818.1};
GN ORFNames=PAL_GLEAN10005882 {ECO:0000313|EMBL:ELK15818.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK15818.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC {ECO:0000256|RuleBase:RU000436}.
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DR EMBL; KB030516; ELK15818.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KYC8; -.
DR STRING; 9402.L5KYC8; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR InParanoid; L5KYC8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691:SF60; INTERFERON ALPHA-5; 1.
DR PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT REGION 216..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 255 AA; 29097 MW; 04ACFD4FA7300CD4 CRC64;
MFPIYDTCRK EGLHSLEAKF GRVTSAARQA SPARSLMALP CSFLVAVVVL SCHSICSLGC
DLPQTHSLVN RRALMLLGQM RRISPFSCLK DREDFGFPQG AFGGNQFQEA QAIAVVHEVT
RQTFHLFCTE VSSAAWDETL LGRFCTGLYQ QLNHLEACQT QEVGTEETPL LDEDSTLAVR
KYFQRITLYL QEKKHSPCAW EIVRAECYDE KKEKQMHSLT SSEGEEYARN EDESRYPLEL
TGRHLKIFEK EEHHE
//
