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Database: UniProt
Entry: L5KYZ1_PTEAL
LinkDB: L5KYZ1_PTEAL
Original site: L5KYZ1_PTEAL 
ID   L5KYZ1_PTEAL            Unreviewed;      2677 AA.
AC   L5KYZ1;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   28-FEB-2018, entry version 24.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|EMBL:ELK16622.1};
GN   ORFNames=PAL_GLEAN10007090 {ECO:0000313|EMBL:ELK16622.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera;
OC   Pteropodidae; Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16622.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y.,
RA   Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y.,
RA   Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G.,
RA   Wang L.F., Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB030441; ELK16622.1; -; Genomic_DNA.
DR   InParanoid; L5KYZ1; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010552};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELK16622.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2222   2247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2259   2277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2289   2309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2345   2370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2390   2412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2519   2542       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2677 AA;  303726 MW;  3D6F8D2B41A78DD5 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDIVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH MDEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGVGVQGR AGRRNAGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDVEEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE
     LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQFLDYLSDL CVSNHIAIPV
     TQELICKCVL DPKNSDILIQ TELRPVKEMA QAHEYLTIEY SEEEVWLTWT DKNNEHHEKS
     VRQLAQEARA GNAHDENVLS YYRYQLKLFA RMCLDRQYLA IDEISQQLGV ELIFLCMADE
     MLPFDLRASF CHLMLHVHVD RDPQELVTPV KFARLWTEIP TAITIKDYDS NLNAARDDKK
     NKFASTMEFV EDYLNNVVSE AVPFANEEKN KLTFEVVSLA HNLIYFGFYS FSELLRLTRT
     LLSIIDCVQG PPAMLQAYED PGGKNVRRSI QGVGHMMSTM SVFGAPSLPG GAGAAEPLDR
     SKFEENEDIV VMETKLKILE ILQFILNVRL DYRISYLLSV FKKEFVEVFP MQDSGADGTA
     PAFDSTSEPY PAPPQVEADL PRAANMNLDR IGEQAEAMFG VGKTSSMLEV DDEGGRMFLR
     VLIHLTMHDY APLVSGALQL LFKHFSQRQE AMHTFKQVQL LISAQDVENY KVIKSELDRL
     RTMVEKSELW VDKKGSGKGE EVETGASKDK KERPTDEEGF LPPPGEKSSE NYQIVRGILE
     RLNKMCGVGE QMRKKQQRLL KNMDAHKVML DLLQIPYDKG DAKMMEILRY THQFLQKFCA
     GNPGNQTLLH KHLHLFLTPG LLEAETMQHI FLNNYQLCSE VSEPVLQHFV HLLATHGRHV
     QYLDFLHTVI KAEGKYVKKC QDMIMTELTN AGDDVVVFYN DKASLAHLLD MMKAARDGVE
     DHSPLMYHIS LVDLLAACAE GKNVYTEIKC TSLLPLEDVV SVVTHEDCIT EVKMAYVNFV
     NHCYVDTEVE MKEIYTSNHI WTLFENFTLD MARVCSKREK RLADPTLEKY VLTVVLDTIN
     AFFSSPFSEN STSLQTHQTI VVQLLQSTTR LLECPWLQQQ HKGSVEACIR TLAMVAKGRA
     ISLPMDLDAH ISLLLSSGAT CVAAAQRNAS NYKAATRAFP RVIPTANQWD YKNIIEKLQD
     IITALEERLK PLVQAELSVL VDVLHWPELL FLEGSEAYQR CESGGFLSKL IQHTKDLMES
     EEKLCVKVLR TLQQMLLKKT KYGDRGNQLR KMLLQNYLQN RKSSSRGDLP DPMGTGLDQD
     WSAIAATQCR LDKEGATKLV CDLITSTKNE KIFQESIGLA IRLLDGGNTE IQHKMEAPGA
     SPSAATPHLT VHPQKSFYNL MTSDKKSERF FKVLHDRMKR AQQETKSTVA VNMSDLGSQP
     REDREPADPT AKSRVASFSM PGSSSLYSLS PSLRRAHEVG ERVQSNEMGM SVLIMQPILR
     FLQLLCENHN RDLQNFLRCQ NNKTNYNLVC ETLQFLDIMC GSTTGGLGLL GLYINEDNVG
     LVIQTLETLT EYCQGPCHEN QTCIVTHESN GIDIITALIL NDISPLCKYR MDLVLQLKVG
     PVAAHDNASK LLLALMESRH DSENAERILI SLRPQELVDV IKKAYLQEEE RENSEVSPRE
     VGHNIYILAL QVAALPIGPV PSNRVPQQLR SVTEHCLLGQ LSRHNKQLQH LLKPVKRIQE
     EEAEGISSML SLNNKQLSQM LKSSPPVQEE EEDPLAYYEN HTSQIEIVRQ DRSMEQIVFP
     VPGICQFLTE ETKHRLFTTT EQDEQGSKVS DFFDQSSFLH NEMEWQRKLR SMPLIYWFSR
     RMTLWGSISF NLAVFINIII AFFYPYVEGA STGALDSPLI SLLFWILICF SIAVLFTKRY
     SIRPLIVALI LRSIYYLGIG PTLNILGALN LTNKIVFVVS FVGNRGTFIR GYKAMVMDVE
     FLYHVGYILT SVLGLFAHEL FYSILLFDLI YREETLFNVI KSVTRNGRSI LLTALLALIL
     VYLFSIVGFL FLKDDFILEV DPLPGNHSRA SPLGMPHGAA TFMDTCSRES IDCVSGVSVP
     QVLEEDEELD NTERACDTLL MCIVTVMNHG LRNGGGVGDI LRKPSKDESL FPARVVYDLL
     FFFIVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVSFEEHI
     KFEHNMWNYL YFIVLVRVKN KTDYTGPESY VAQMIKNKNL DWFPRMRAMS LVSNEGEGEQ
     NEIRILQDKL NSTMKLVSYL TAQLNELKEQ VCTPALS
//
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