ID L5KZK3_PTEAL Unreviewed; 1751 AA.
AC L5KZK3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Triple functional domain protein {ECO:0000313|EMBL:ELK16832.1};
GN ORFNames=PAL_GLEAN10014121 {ECO:0000313|EMBL:ELK16832.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16832.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KB030429; ELK16832.1; -; Genomic_DNA.
DR STRING; 9402.L5KZK3; -.
DR eggNOG; KOG0032; Eukaryota.
DR eggNOG; KOG4240; Eukaryota.
DR InParanoid; L5KZK3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11852; SH3_Kalirin_1; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR028570; Kalirin_TRIO_SH3_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..189
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1282..1457
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1469..1581
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1646..1711
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1591..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 736..763
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1618..1635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1751 AA; 200727 MW; 5E0E8A9B26B9DCA6 CRC64;
MKAMDVLPIL KEKVAYLSGG RDKRGGPILT FPARSNHDRI RQEDLRRLIS YLACIPSEEV
CKRGFTVIVD MRGSKWDSIK PLLKILQESF PCCIHVALII KPDNFWQKQR TNFGSSKFEF
EALLRIRVSA AGMNLQSHRS RGAGVEAAAP SSSAAHRGVT NMVSLEGLTK VVDPSQLTPE
FDGCLEYNHE EWIEIRVAFE DYISNAGHML SRLEELQDIL AKKELPQDLE GARNMIEEHS
QLKKKVIKAP IEDLDLEGQK LLQRIQSSDS FPKKNSGSGN ADLQSLLPKV SAMLDRLHST
RQHLHQMWHV RKLKLDQCFQ LRLFEQDAEK MFDWITHNKG LFLNSYTEIG TSHPHAMELQ
TQHNHFAMNC MNVYVNINRI MSVASRLVES GHYASQQIKQ IASQLEQEWK AFAAALDERS
TLLDMSSVFH QKAEKYMSNV DSWCKACGEV DLPSELQDLE DAIHHHQGVY EHVTLAYSEV
SQDGKSLLDK LQRPLTPGSS DSLTASANYS KAVHHVLDVI HEVLHHQRQL ENIWQHRKVR
LHQRLQLCVF QQDAALVLDW IENHGEAFLS KHTGVGKSLH RARALQKRHE DFEEVAQNTY
TNADKLLEAA EQLAQTGECD PEEIYQAAHQ LEDRIQDFVR RVEQRKILLD MSVSFHTHVK
ELWTWLEELQ KELLDDVYAE SVEAVQDLIK RFGQQQQTTL QVTVNVIKEG EDLIQQLRDS
AISSNKTPHS SSIGHIETVL QQLDEAQAQM EELFQERKVK LDLFLQLRIF ERDAIDIISD
LESWNDELSQ QMNDFDTEDL TIAEQRLQHH ADKALTMNNL TFDVIHQGQD LLQYVNEVQA
SGVELLCDRD VDMATRVQDL LEFLHEKQQE LDLAAEQHRK HLEQCVQLRH LQAEVKQVLG
WIRNGESMLN AGLITASSLQ EAEQLQREHE QFQHAIEKTH QSALQVQQKA EAMLQANHYD
MDMIRDCAEK VASHWQQLML KMEDRLKLVN ASVAFYKTSE QVCSVLESLE QEYKREEDWC
GGADKLGPNS ETDHVTPMIS KHLEQKEAFL KACTLARRNA XXXXXXXXXX XDVFLKYLHR
NSVNVPGMVT HTKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY VVFERSAKQA
LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI QLADGFCEKG
HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ LDIIPASIPG
SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW EMTSGVEEIP
PGIVNKELVI FGNMLEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF QMYVTYCKNK
PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL TCCEEGKGEI
KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL IRKGRERHLF
LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG RTPTSDNKIV
LKASSIENKQ DWIKHIREVI QERTIHLKGA LKEPIHLPKT APATRQKGRR DGEDLDSQGD
GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSTELTIRRG QTVEVLERPH
DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKVRSVSE PIVIHPGPIP
PPPAPFLTLR V
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