ID   L5L043_PTEAL            Unreviewed;      1004 AA.
AC   L5L043;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 12 {ECO:0000313|EMBL:ELK16795.1};
GN   ORFNames=PAL_GLEAN10000717 {ECO:0000313|EMBL:ELK16795.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK16795.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB030432; ELK16795.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5L043; -.
DR   STRING; 9402.L5L043; -.
DR   eggNOG; ENOG502QS9E; Eukaryota.
DR   InParanoid; L5L043; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF11; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 4.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 9.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          1..95
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          211..528
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   1004 AA;  114119 MW;  76C97C3D777C1DA2 CRC64;
     MPRTVVKDGL CRLSVYLEEL EAVELKKFKL HLGTATDMGE DGIPWGRMET AGPLEMAQLL
     VAHYGIGEAW VLALSIFDRI NRKDLWERGQ REDLVMDTSP GGLSSLGSQS ACSLKIFTGT
     PRKDPRETYR DYVRRKFRLM EDRNARLGEC VNLSHRYTRL LLVKEHSNPM WAQQKLLDTG
     WGHARTIGHQ TSLIQMETLF EPDEERPEPP RTVVLQGAAG MGKSMLAHKV MLDWADGRLF
     RDRFDYVFYI HCREMNQSAS DQSVQDLLSS CWPEPSAPLW ELVQVPERLL FIIDGFDELR
     PSFHDSQGPC CLCWEEKQPT ELLLSSLIRK KLLPELSLLI TTRPAALEKL HRLLEHPRHV
     EVLGFSEAER KEYFYKYFHN TEQAGQVFNF VRDNEPLFTL CFVPLVCWVV CTCLKQQLEG
     GGLLRQTSRT TTAVYMLYLL SLMQPKPGSP TLQPPPNQRG LCSLAADGLW NQKILFEEQD
     LRKHGLDGVD VSSFLNMNIF QKDINCEKFY SFIHLSFQEF FAAMYYIMDG GESGASPHQN
     LRRLLAEYAF SERSFLALTV RFLFGLLNEE TRSYLEKCLC WKVSPHIKVE LLQYIQSKAQ
     SEGSTLQRGS LEFLSCLYEL QEKEFIQQAL GHFQVVVVSS ITTKMEHMVS SFCMKNCRSI
     LVLHLYGAAY SADEEDGARW TSGPRMPLTP SPERNILPDA YSEQLAAALS TNPNLMELAL
     YRNALGNRGV KLLCQGLQHP NCKLQNLRLK RCLVSSSACQ DLTAALMTNK NLMRMDLSSN
     DLGLPGLKLL CEGLQHPKCR LQMIQLRKCH LEARACQEMA SVLSTSRHLV ELDLTGNALE
     DLGLKLLCQG LRNPVCRLQI LWLGICRLSS AACEGLSTVL QLNRHLRELD LSFNDLGDRG
     MWLLCEGLRH PTCRLQKLWL DSCGLTAKAS EDLSSILGVN QTLIELYLTN NSLGNTGVRL
     LCKRLSHPGC KLRVLWLFGM DLNKMTHRRL AALRVTKPYL DIGC
//