ID L5L1L7_PTEAL Unreviewed; 1191 AA.
AC L5L1L7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=PAL_GLEAN10009375 {ECO:0000313|EMBL:ELK17639.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK17639.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; KB030402; ELK17639.1; -; Genomic_DNA.
DR RefSeq; XP_015455375.1; XM_015599889.1.
DR AlphaFoldDB; L5L1L7; -.
DR STRING; 9402.L5L1L7; -.
DR eggNOG; KOG0933; Eukaryota.
DR InParanoid; L5L1L7; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 520..640
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 246..365
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 402..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 681..937
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 984..1011
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1191 AA; 135029 MW; BF1AA0589A7041CD CRC64;
MHIKSIVLEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS
NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV
NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA
AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL
LAEDTKERSA EELKEMQDKI VKLQEELCEN DKKIKALSQE IEELEKRKDK ETGGILRSLE
DALAEAQRVN TKSQSAFDLK KKNLTSEENK RKELEKNMIE DTKTLAAKEK EVKKITDGLN
TLQEANNKDA EALATAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ
MKLKHAQQEL KTKQAEVKKM DSGYRKDQEA LEAVKKLKEK LEAEMKKLNY EENKEESLLE
KRRQLSRDIS RLKETYEALL ARFPNLQFAY RDPEKNWNRN CVKGLVASLI SVKDTSATTA
LELVAGERLY NVVVDTEVTG KKLLEKGELK RRYTIIPLNK ISASRIAPET LRIAQNLVGP
NNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDIFDPH
GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELQALEE ELAGLKNTAE KYRRLKQQWE
MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQKKAE EKYEVLENKM
KNAEAEREKE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHASCEQQL
EAVNEAIRSY EGQIEVMAAE VAKSKESLHK AQEEMTKQKE VITAQDNVIK TKYAEVAKHK
EQNNDSQLKI KELDHNISKH KREAEDAAAK VSKMLKDYDW INAEKHLFGL PNSAYDFKTN
NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILATIE
DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE
NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF
IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKVP KETKSKAKGP K
//
