ID L5L1Z5_PTEAL Unreviewed; 1738 AA.
AC L5L1Z5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Alpha-catulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=PAL_GLEAN10009404 {ECO:0000313|EMBL:ELK17662.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK17662.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000256|ARBA:ARBA00009773}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR EMBL; KB030402; ELK17662.1; -; Genomic_DNA.
DR STRING; 9402.L5L1Z5; -.
DR eggNOG; KOG2365; Eukaryota.
DR InParanoid; L5L1Z5; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 4.
DR InterPro; IPR002549; AI-2E-like.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR030045; CTNNAL1.
DR InterPro; IPR006077; Vinculin/catenin.
DR PANTHER; PTHR46342; ALPHA-CATULIN; 1.
DR PANTHER; PTHR46342:SF1; ALPHA-CATULIN; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
DR Pfam; PF01044; Vinculin; 2.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 312..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1738 AA; 193561 MW; 0179A1CFE40838ED CRC64;
MASQYRLSEA AGRQQRRHGX XXXXXXXXXX XXXXXXXXXX XXXGGSGGGC GETPRTAALA
LRFDKPIKQA FYNTGAVLFV CLCCGAAVLV YFILEAFLRP LLWAVLCGTF LHPFKSSLTR
LGRHWLQRLH RAHTPIVLAA LLLPLCFADY GVEALGEQAL RRRRLLVLLG AGGPLLYGLY
SLGSYLGVQV LLAHAGALIC RGLDYFSSLW IWTLVVGYVL TVSFKWNAST ERYLRAVSIP
VWIILLFHLA SLAGSWRIPV FLVIVFLMSV GTLYEKQNGK ESSGAELPGQ VISMAASTLA
TLAISITGYE SSTEDRSSTQ PAETMDRGEP PATVSSSPSP SSPSPSLGRQ KSEVGTFLRK
KKTSDTYFVS LLWAIIGVQI WLNLWIVQLL PVPVAVWILK KLVIHFGVVN FLEKRCYAWW
QVVEHFLKER QEALAPWPII GLGKFLLKVD SKMIIWLEKM LDKIISIFII FLLVIGTLLL
ALLLTAKVHQ ESVHMIEVTS SLINETLANH PEWANWLPEA QVVQRALNSA ANNVYQYGRE
WITHKLHKIL GDKVNNTAVI EKQVLELWDR LYHSWFVKNV THSGRHKGHK MHMSRQNSWL
GDILDWQDIA SFVHENIETF LSILESLWIV MSRNVSLLFT TVTTLLTILF YSGTALLNFV
LSLIIFLTTL FYLLSSSDEY YKPVKWVISL TPLSQPGPSS NIIGQSVEEA IRGVFDASLK
MAGFYGLYTW LTHTIFGINI VFIPSALAAI LGAVPFLGTY WAAIPAVLDL WLTQGLGCKA
ILLLIFHLLP TYFVDTAIYS DISGGGHPYL TGLAVAGGAY YLGLEGAIIG PILLCILVVA
SNIYSAMLVS PTNSAPTPNQ TPWPAQTQRP PWRVGVRTQL PGCRGPTPAG APLTRRGPPR
WCCLIQYWRT FASPAQTRTG GHYGWGIPSP ACSPEAFVPL PGVCVGSPSP IHPGPPCSFA
LACSLQLAFV RPREKVCNQL IDALGFREVF VTVSRLIRSL RARIPQLDLL CAKHCGEWRT
PCLQERVGDA CDSQLDGNVF MTHISIAKIL EITTLINHKH NTKKSDKTLQ AIQRVGQAVN
LAVGRFVKVG EAIANENRDL KEEINIACIE AKQAGETIAA LTDVGSLNHP ESDGQITIFT
DKTGVIKAAR LLLSSVTKVL LLADRVVIKQ IITSRNKVLA TMERLEKVNS FQEFVQIFSQ
FGNEMVEFAH LTGDRQNDLK DEKKKAKMAA ARAVLEKCTM MLLTASKTCL RHPNCESAHK
NKEGVFDRMK VALDKVIEIV TDCKPNGETD ISSITVFTGI KEFKINIETL RENRYFQSKE
SLSATLEAIL ERTEDFTDSA STSHEHRERI LELSTQARME LQQLTSVWIQ AQNQKTKSIA
EELELSILKI SHSLNELKKE LHSTATQLAA DLLKYHADHV VLKALKLTGV EGNLEGLAEY
ACKLSEQKEQ LVESCRLLRH VSGTEPLEIT CIHAEETFQV TGQQIISAAE TLTLHPSSKI
AKENLDVFCE AWESQISDMS TLLREINDVF EGRRGEKYGY LSLPKPMKNN ANLKSLKPDK
SDSEEKARIA KLGLKLGLLT SDANCEIEKW ENQENEIVRY GRNMSSMAYS LYLFTRGEGP
LNTSQDLIHQ LEVFAEEGLK LASSVQAFSK QLKDDDKLML LLEINKLIPL CHQLQTITKT
PLQNQVFLKV DKCITKTRSM MAILVQLLSL CFKLLKKFQM ENNRWVSVTN KDSVDGKT
//
