ID L5L2V9_PTEAL Unreviewed; 1494 AA.
AC L5L2V9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=CLIP-associating protein 2 {ECO:0000313|EMBL:ELK17962.1};
GN ORFNames=PAL_GLEAN10012810 {ECO:0000313|EMBL:ELK17962.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK17962.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR EMBL; KB030368; ELK17962.1; -; Genomic_DNA.
DR STRING; 9402.L5L2V9; -.
DR eggNOG; KOG2956; Eukaryota.
DR InParanoid; L5L2V9; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF30; CLIP-ASSOCIATING PROTEIN 2; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 303..536
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 845..1082
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1241..1487
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 245..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1256..1284
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 251..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1494 AA; 163940 MW; 8BAE50EA2BB2A521 CRC64;
MEPRSMEYFG AQVQQKDVGG RLQVGQELLL YLGAPGAIPD LEEDLGSLRK TIDALTGWVG
SSNYRVSLMG LEILSAFVDR LSTRFKSYVA MVIVALIDRM GDAKDKVRDE AQTLILKLMD
QVAPPMHIWE QLASGFKHKN FRSREGVCLC LIETLNIFGA QPLVLSKLVP HLCILFGDSN
SQVRDAAILA VVEIYRHVGE KVRVDLSKRG ISPARLEMIF AKFDEVQNSG GMILTVCRDK
SFDDEESVDG NRPSSASSAF KVPAPKTSGN PVNSASKEGG AGAVDEDDFI KAFTDVPSIQ
IYSSRELEET LNKIREILSD DKHDWDQRAN ALKKIRSLLV AGAAQYDCFF QHLRLLDGAL
KLSAKDLRSQ VVREACITVA HLSTVLGNKF DHGAEAIVPT LFNLVPNSAK VMATSGCAAI
RFIIRHTHVP RLIPLITSNC TSKSVPVRRR SFEFLDLLLQ EWQTHSLERH AAVLVETIKK
GIHDADAEAR VEARKTYMGL RNHFPGEAET LYNSLEPSYQ KSLQTYLKSS GSVASLPQSD
RSSSSSQESL NRPFSSKWST ANPSTVAGRV SAGSSKASSL PGSLQRSRSD IDVNAAAGAK
AHHAAGQSMR SGRLGAGALN PGSYASLEDT SDKMDGTASE DGRVRAKLST PLAGMGNAKT
DSRGRSRTKM VSQSQPGSRS GSPGRVLTTT ALSTVSSGVQ RVLVNSASAQ KRSKIPRSQG
CSREASPSRL SVARSSRIPR PSVSQGCSRE ASRESSRDTS PVRSFQPLGP GYGISQSSRL
SSSVSAMRVL NTGSDVEEAV ADALKKPARR RYESYGMHSD DDANSDASSA CSERSYSSRN
GSIPTYMRQT EDVAEVLNRC ASSNWSERKE GLLGLQNLLK NQRTLSRVEL KRLCEIFTRM
FADPHGKVFS MFLETLVDFI QVHKDDLQDW LFVLLTQLLK KMGADLLGSV QAKVQKALDV
TRESFPNDLQ FNILMRFTVD QTQTPSLKVK VAILKYIETL AKQMDPGDFI NSSETRLAVS
RVITWTTEPK SSDVRKAAQS VLISLFELNT PEFTMLLGAL PKTFQDGATK LLHNHLRNTG
NGTQSSMGSP LTRPTPRSPA NWSSPLTSPT NTSQNTLSPS AFDYDTENMN SEDIYSSLRG
VTEAIQNFSF RSQEDMNEPL KRDSKKDDGD SMCGGPGMSD PRAGGDATDS SQTVLDNKAS
LLHSVPAHSS PRSRDYNPYN YSDSISPFNK SALKEAMFDD DADQFPDDXX XXXXXHSDLV
AELLKELSNH NERVEERKIA LYELMKLTQE ESFSVWDEHF KTILLLLLET LGDKEPTIRA
LALKVLREIL RHQPARFKNY AELTVMKTLE AHKDPHKEVV RSAEEAASVL ATSISPEQCI
KVLCPIIQTA DYPINLAAIK MQTKVIERVS KETLNLLLPE IMPGLIQGYD NSESSVRKAC
VFCLVAVHAV IGDELKPHLS QLTGSKMKLL NLYIRRAQTG SGGADPTTDV SGQS
//
