ID L5LCM2_MYODS Unreviewed; 519 AA.
AC L5LCM2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Amiloride-sensitive sodium channel subunit delta {ECO:0000313|EMBL:ELK23616.1};
GN ORFNames=MDA_GLEAN10007543 {ECO:0000313|EMBL:ELK23616.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK23616.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; KB113360; ELK23616.1; -; Genomic_DNA.
DR AlphaFoldDB; L5LCM2; -.
DR eggNOG; KOG4294; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:ELK23616.1};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 324..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 57479 MW; C2B605CD2BC7FBDF CRC64;
MEEGPGEPLV ELPGSFRELF TFFCANTTVH GTIRLICSSQ NRLKTASWGL LFLGALGALY
WQFGLLFEQY WRYPVIMTVS MHSEGKLFPS VTLCDMNPHR PSPVRTHLQA LDAFAQENIY
ALYRFNLSTS GAIPPVEDPG PSPAFQLDRR VRLERLSGPG SQNKVGFRLC NSTGGDCFYR
AYSSGVTAVR AWYRFHYVNI LALLPRSPED NHQSHGGHFV FSCRYNGEDC EAQHFRTFHH
PTYGSCYTVN GMWTAQRPGI THGISLILRA EQQDDLPLLS TEAGIKVMVH TRDHTPFLEH
RGFSIRPGTE TTIGIREVWG RGGKQRRAGL PRPCPALESE GGRMELNPSP QDEVHRLGSP
YSDCTDSGEG VDVPLLYNAT YTRQVRPGSG SNVAKVNIFY QELNYRTVDE TPVYSVPQLL
SAMGSQWSLW FGSSVLSVLE LLELLIDAVA LAVLLGCHRL RRAQGSRPQA AHTKPETNQV
PGDYGHDAPR PGAQPATPPG VLAGVSAEEL GQAWVPQDS
//
