ID L5LGZ5_MYODS Unreviewed; 859 AA.
AC L5LGZ5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Niemann-Pick C1-like protein 1 {ECO:0000313|EMBL:ELK25166.1};
GN ORFNames=MDA_GLEAN10006458 {ECO:0000313|EMBL:ELK25166.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK25166.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB112287; ELK25166.1; -; Genomic_DNA.
DR AlphaFoldDB; L5LGZ5; -.
DR eggNOG; KOG1933; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..859
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003970186"
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..445
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 859 AA; 94133 MW; BBB4822315902C74 CRC64;
MAVVAALAWG LAFLAGGLAF TKLTTDPVEL WSAPNSQARR EKAFHDQHFG PFFRTNQVIL
TAPSRPSYQY DSLLLGPKTF GGVLGTDLLL ALLELQERLR HLQVWSPQEQ RNVSLRDVCY
APLNPDNASL ADCCINSLLQ YFQSNRTRLL LTANQTLTGQ TAQVDWRDHF LYCANAPLTF
KDGTALALSC MADYGAPVFP FLAVGGYQGN EYSAAEALIL TFSLNNYPPG DPRLAQARLW
EGAFLEEMRA FQRQMAGTLQ VTFMAERSLE DEISRTTAED LPIFAISYLV IFLYISLALG
SYTSWRRMLV DAKVTLGLGG VAVVLGAVMA AMGLFAYLSV PSSLVVLQVV PFLVLAVGAD
NIFIFVLEYQ RLPRRPGERR EVHIGRALGR VGPSMLLCSV SEAVCFFLGA LTPMPAVRTF
ALTSGLALIL DFLLQMSAFV ALVSLDSRRQ EVLLFLALFG VGLYFMCHIS VGLDQELALP
KDSYLLDYFL FLSRYFEVGA PVYFVTTGGY NFSSTVGMNN ICSSAGCESF SLTQKIQYAT
EFPEQSYLAI PASSWVDDFI DWLTPSSCCR LYAFGPSKDQ FCPSTVNSLA CLKNCVGFTL
GPVRPSVDQF HKYLPWFLSD APNIKCPKGI TNVFYEQYLT VVPEGLFMLS LCLVPTFAVC
CLLLGMDLRS GLINLFSILM ILVDTVGFMA LWGISYNAVS LINLVTAVGI SVEFVSHITR
SFAVSTKPTR LERAKEATIS MGSAVFAGVA MTNLPGILIL GLAKAQLIQI FFFRLNLLIT
LLGLLHGLVF LPVVLSYLGP DINMALVLEQ KRAEEAAAAR TASCKKHSFP ESWANGTYVN
HGFQHPAGSG VSSGDPPPQ
//
