ID   L5LPM1_MYODS            Unreviewed;       995 AA.
AC   L5LPM1;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Pleckstrin like proteiny domain-containing family M member 2 {ECO:0000313|EMBL:ELK27967.1};
GN   ORFNames=MDA_GLEAN10024328 {ECO:0000313|EMBL:ELK27967.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK27967.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB109639; ELK27967.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5LPM1; -.
DR   eggNOG; KOG4381; Eukaryota.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd13309; PH_SKIP; 1.
DR   CDD; cd17680; RUN_PLEKHM2; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR047327; RUN_PLEKHM2.
DR   PANTHER; PTHR46556; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR   PANTHER; PTHR46556:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   4: Predicted;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        242..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..161
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          808..910
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          276..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          506..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  109678 MW;  494DE0A7019C7945 CRC64;
     MVYRSLLHKE NEMWPCCCGS VCSLQSYFAA CEDETPAIRN HDKVLQRLCE HLDHALLYGL
     QDLSSGYWVL VVHFTRREAI KQIEVLQHVA TNLGRSRAWL YLALNENSLE SYLRLFQENL
     GLLHKYYVKH ALVCSHDHLT LFLTLVSGLE FIRFDLDLDA PYLDLAPYMP DYYKPQHLLD
     FEDRLPSSAH GSDSLSLNSF NSVTSTNLEW DDSAIAPSSE DYDFGDVFPA VPSVPSTDWE
     GLLLLLLVVV VVVVVMVVVM VVVVVMVVVV VPRNGDLTDT VSGPRSTASD LTSSKASTKS
     PTQRHNPFNE EQAEALSSSD TTPVHTASQG KEPHPSELLD AGTELEVIRV TKKKKTGKKK
     KTRSDEEASP LRPASAQHTG ARRGDGDSRV SSPGLGRGSP DTTLASPQEK GEGLAESSER
     SEPSQMGLLI PEMKDTSMER VGQPLSKVID QLNGQLDPRT WCSHVEPPDQ PFRTGSPGDT
     PERPPFCDFS EGLPAPMDFY RFTVESPSTV TSGGGHHDPA GPRQPLHVPG GPAAAGQEEE
     GGGGGEGEAP PPLGATQEPE TRAPETQVPP VKEGPGPEPE SGTQEALCQL KRDQPSPCLS
     SAEDSGVEEG QGSPSEMSHS AEFRVDNNHL LLLMIHVFRE NEEQLFKMIR MSTGHMEGTL
     QLLYVLLTDC YVYLLRKGAT EKPYLVEEAV SYNELDYVSV GLDQQAVRLV CTNRRKQFLL
     DTADAALAEF FLASLKSAMI KGCREPPYPS ILTDATMEKL ALAKFVAQES KCEAAAVTVR
     FYGLVHWEDP TDESLGPVPC HCSPPEGAIT KEGMLHYKAG TSYLGKELWK TCFVVLSNGI
     LYQYPDRTDV IPLLSVNMGG EQCGGCRRSN TTDRPHAFQV ILADRPCLEL SAESEAEMAD
     WMQHLCQAVS KGEFSRDGQQ PLPPWVIYLS CTSELDRFLS ALNSGWRTIY QVDLPHKAIQ
     EASHKKFEDA LSLIHSAWQR SDSLCRGRAS RDPWC
//