ID L5LQF7_MYODS Unreviewed; 3466 AA.
AC L5LQF7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Dynein heavy chain 7, axonemal {ECO:0000313|EMBL:ELK27728.1};
GN ORFNames=MDA_GLEAN10023668 {ECO:0000313|EMBL:ELK27728.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK27728.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB109900; ELK27728.1; -; Genomic_DNA.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF07728; AAA_5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 1814..1849
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3437..3466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2405..2446
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3452..3466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3466 AA; 396479 MW; 122EA27DC0B259A3 CRC64;
MSREQEKSAS REKEKDRGKQ PARLLPQLAT VSTKPQWQEA APSFHLNVKQ EEDIPEPFSV
KNEQSYAEYM EHFGRKGTLL DQIDDSCAGP STSKAKSKFP HKERENFRST LVNVIMQQDA
LSDVPAPEES AFPKMTTSAI EKDILRYYYY IHHGIDTDHI APMEDSWLEN VLNLVPQHLK
VLTDSILTLS DEMREDYLLS VKKSIVDFVL KDPREKDDKK AEELPPHRAE MEILPKPWRK
SFLAASSYIR DHLNAMNPTM LAVLDLWHST FKWFPEVQNI YYQGNKKKQL PTGESSAKLE
AFFNCAAALM TLQLQDLTLS SMQDFTDLIA QPPDSNSKPT TLAPVILEEI VEAHKEKVKE
VIMRESAAPI EHLKLYDKYD FLITRKAEKD VDAFLAENHH YEKIIQEIRK YQQLIEDIQY
TTRKAYIKKV ETVDMIELGR RLVDSKNCLA FLIECTTFSP ADIRLNNNAF QWYGRMEEIF
DEHRRIIAEK TEQYQDGLKL RCQRFVEELE SYAKQSEEFY ALGDLQDVQR YLKKAQTLNG
KLDLAADKIE QFNAEEEAFG WPPSLYPQRK KIQDSLNPYL RLYETAVEFS TKYRAWTEGP
YHKVDPDQVE VDVGNYWRGL YKLEKTFNDS PNALAMTKKV KAKVEDFKQH IPLIQVICNP
GLRPRHWEAM SNIVGFPLQP ADESTVSPFL DMNLEQYLDR FEGISEAASK EYTLEKTLEK
MIKEWDSMEF VLLSYRESGT SILSSVDEIQ MLLDDHIIKT QTMRGSPFIK PYEKQIREWE
GKLLLLQEIL DEWLKVQATW LYLEPIFSSP DIMSQMPEEG RRFTTVDKTW RDIMKTLLQD
KHVLSVVTID KMLERLKKSN ELLELILKGL NEYLEKKRLF FPRFFFLSND ELLEILSETK
DPTRVQPHLK KCFEGIARVE FTETLDITHM KSSENEVVEL IETISTVKAR GQVEKWLVEL
ERVMIRSIRK VIKSAITAYT QYERIKWVRV WPGQTVLCVS QTYWTTEVQA AISKGQEALE
EYLEKCNSQI DDIVTLVRGK LSKQNRVTLG ALVVLDVHAR DVLTSLVNKK VSDESDFEWL
SQLRYYWQDN NLETKMINAG LRYGYEYLGN SPRLVITPLT DRCYRQTLFG ALHLHLGGAP
EGPAGTGKTE TTKDLAKAVA KQCVVFNCSD GLDYLALGKF FKGLLSCGAW ACFDEFNRID
LEVLSVVAQQ ILTIQRGINA GADTLVFEGT ELKLDPTCAV FITMNPGYAG RSELPDNLKA
LFRTVAMMVP DYAMIAEIVL YSCGFVTARP LSVKIVATYR LCSEQLSSQH HYDYGMRAVK
SVLTAAGNLK GITSDLFPGV KLPKPDYNDL LMAIKDNCEA MNLQMTSFFS EKILQIYEMM
IVRHGFMIVG EPFGGKTSAY RVLAGALSDI CEKGLMEENK VQITVLNPKS VTMGQLYGQF
DQVSHEWSDG VLAVSFRAFA SSMTPDRKWL IFDGPVDAVW IENMNTVLDD NKKLCLMSGE
IIQMSPQMNL IFEPMDLEVA SPATVSRCGM IYMEPHMLGW RPLMLSWVNL LPATLNATQK
EFLVTLFDRM VPVSVEFIRK HTKELSPTSD TNLVRSLMNL IDCFMDEFAD EVKVRERNDR
EAYSLLENFL LTQINKEIYK PLLINFSAQT TAAQTQNIIM SKLDKRRKGV FGPPLGKKMV
VFVDDVNMPA REVYGAQPPI ELLRQWLDHW NCYKFPEDFL TLTAQIVNGT MILYKEAMKN
LLPTPAKSHY LFNLRDFSRV IQGVCLSRPE TTATKEAIKR LWVHEVLRVY YDRLLDNADR
RWLIEYIQEI LTHHMYENFH ELFQHLDFNG DGVVEEDDLR SLMFCDFHDP KKEDTNYREV
ENVDSLRMIV ETHLEEYNNM SKKTMSLVLF RFAIEHISRI SRILKQPRSH ALLVGVGGSG
RQSVTRLAAH MADYSVFQVE ITKGYGNTEW HEDLKVILRK CAEGEMHGVF LFTDTQIKRE
SFLEDVNNLL NAGEVPNLFA LDEKQEICEK MRQLDRQRDK TKQTDGSPIA LFNMFIDRCR
SQLHVVLAMS PIGDAFRIRL RKFPALVNCC TIDWFQSWPE DALQAVASRF LEEIEMSEEI
RDGCIDMCKS FHTSTIDLST SFHVELQRYN YVTPTSYLEL ISTFKLLLEN KRSEVMKMKK
RYEVGLEKLD SAASQVASMQ LELEALHPQL KVASKAVDEM MLMIERESFE VAKTEKIVKA
DEIVANEQTM AAKAIKDECD ADLAGALPIL ESALAALDTL TAQDITVVKS MKSPPAGVKL
VMEAICILKG IKSDKIPDPT GSGKKIEDFW GPAKRLLGDI RFLQSLHEYD KDNIPPAYMN
IIRKNYIPNP DFVPEKIRNA STAAEGLCKW VIAMDSYDKV AKIVAPKKIK LAAAEAELKV
AMDGLRKKQA ALHEVQDKLA KLQDKLEQNK EKKADLENQV RMVQANAGKL STIVDLCSKK
LERAEQLIGG LGGEKTRWSQ SALELGLLYI NLTGDILISS GVVAYLGAFT SNYRQNQVKE
WTDLCKGRGI PCSEDYSLMG TLGEAVTIRT WNIAGLPSDS FSIDNGIITM NARRWPLMID
PQGQANKWIK NMEKTNSLQL IKFSDPDYVR TLENCIQFGT PVLLENVGEE LDPILEPLLL
KQTFKHGGST CIRLGAPVPQ LELGDCTHLV LCRRDPRSSG AGVQEQDMGA LLRPFYGLLS
RTAFALKSNS RVQSPVGQLK EIEDKILEVL SSSEGNILED ETAIKILSSS KALANEISQK
QEVAEETERQ IDTTRMGYRP IAIHSTILFF SIADLANIEP MYQYSLNWFI NLFILSIENS
ENSDILSKRL QILRDHFTYS LYVNVCRSLF EKDKLLFSFC LTVNLQIHEH AINKAEWRFL
LTGGIGLDNP YTNPCTWLPQ KSWDEICRLD ELPSFKAIRK EFMHLKDGWK RVYDSLEPHH
EAFPEAWEDK MNDFQRMLII RCLRPDKVIP MLQEFISSKL GRMFIEPPPF NLSKAFADSN
CCAPLIFVLS PGADPMAALL KFADDQELSP ESTHPDFRMW LTSYPSPNFP VAVLQNGVKM
TNEAPKGLRA NIIRSYLMDP ISDPEFFDSC KKPAEFKKLL YGLCFFHALV QERRKFGPLG
WNIPYEFNET DLRISVQQLH MFLNQYEELP YDALRYMTGE CNYGGRVTDD WDRRTLRSIL
NKFFCTQLVE DPGYKFDSSG IYFAPPPGEH KSYIEYTQTL PLTPAPEIFG MNANADITKD
QSETQLLFDN ILLTQSRSAE AGAKSSEEVL NEVAGDILGK LPNNFDLEAA MRRYPTTYTQ
SMNTVLVQEM GRFNKLLQTI RESCINIQKA IKGLLVMSTD LEEVVSSILN VKIPGMWMAK
SYPSLKPLGS YVNDFLTRLR FLQQWYEVGP PPSFWLSGFF FTQAFLTGAQ QNFARKYTIP
IDLLGFDYEV LEDKDYKVPP EDDDKTGLKL KELPQVTSTS GTKAQA
//
