ID L5LR07_MYODS Unreviewed; 447 AA.
AC L5LR07;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Tektin {ECO:0000256|RuleBase:RU367040};
GN ORFNames=MDA_GLEAN10007638 {ECO:0000313|EMBL:ELK28445.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28445.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. Required for normal sperm mobility.
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SIMILARITY: Belongs to the tektin family.
CC {ECO:0000256|ARBA:ARBA00007209, ECO:0000256|RuleBase:RU367040}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB109242; ELK28445.1; -; Genomic_DNA.
DR RefSeq; XP_006766257.1; XM_006766194.1.
DR AlphaFoldDB; L5LR07; -.
DR GeneID; 102771255; -.
DR KEGG; myd:102771255; -.
DR eggNOG; KOG2685; Eukaryota.
DR OrthoDB; 2875854at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:UniProtKB-UniRule.
DR InterPro; IPR048256; Tektin-like.
DR InterPro; IPR000435; Tektins.
DR PANTHER; PTHR19960; TEKTIN; 1.
DR PANTHER; PTHR19960:SF12; TEKTIN-4; 1.
DR Pfam; PF03148; Tektin; 1.
DR PRINTS; PR00511; TEKTIN.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|RuleBase:RU367040};
KW Cilium {ECO:0000256|RuleBase:RU367040};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Flagellum {ECO:0000256|RuleBase:RU367040};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT REGION 72..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 308..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 378..422
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 447 AA; 51828 MW; 48C07F8D1DD635B4 CRC64;
MAQSDVLLTK QPAPQTVPAC ELPPKLYDVA RNTGAHTSAG LATAGFRAAK YLVDEWFQNS
YASYHQAFAD RDQSERQRHE SRQLAAETGA LAQRTQEDST RKVGERLQDM HCWKSELQRE
VGELVAETDL MLAQKQRLER ALDATGVPFS IATDNLQCRE RRQHPDLVRD YVEVELLKEA
ELIRNIQELL KRTIMQAVNQ IRMNREHKEL CEMNWCDKVE AYNIDETCAR YNNQSTEVQF
HPHSTKFEES ASTPETWARF TQENLQRAER ERLASFNLRG LIDGILRDTS EDLRLQCDSV
NLAFGRRLEE LEDARHKLEH HLNKTLREIA DQEHNIAELK QAIRDKEVPL KVAQTRLYQR
SQRPNVELCR DTAQFRLVSE VEELNRSLSA LKEKLLEAEQ SLRNLEDTRM SLEKDVAVKT
NSIFIDSQKC MTRRAHYPTV LRLAGYQ
//
