ID L5LT87_MYODS Unreviewed; 1899 AA.
AC L5LT87;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Myosin-7B {ECO:0000313|EMBL:ELK29644.1};
GN ORFNames=MDA_GLEAN10022759 {ECO:0000313|EMBL:ELK29644.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK29644.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KB107934; ELK29644.1; -; Genomic_DNA.
DR eggNOG; KOG0161; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14927; MYSc_Myh7b; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF50084; Myosin S1 fragment, N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 30..89
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 93..786
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 663..685
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1862..1899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 186..193
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1899 AA; 216978 MW; CE00EB3EE4FAD425 CRC64;
MMDVSELGES ARYLRQGYQE MMKVHTVAWD GKKRVWVPDE QDAYVEAEVK SEATGGRVNV
ETKDQKDSAA WPPWQMLMVR EAELQPMNPP RFDLLEDMAM MTHLNEASVL HNLRQRYARW
MIYTYSGLFC VTINPYKWLP VYTPSVVAAY KGKRRSEAPP HIYAVADNAY NDMLRNRENQ
SMLITGESGA GKTVNTKRVI QYFAIVAALG DGPGKKAGTL EDQIIEANPA MEAFGNAKTL
RNDNSSRFGK FIRIHFGPSG KLASSDIDSY LLEKSRVIFQ LPGERGYHVY YQILSGKKPE
LQDMLLLSVN PYDYHFCSQG VITVDNIDDG EELMATDHAM DILGFSVDEK CACYKIVGAL
LHFGNMKFKQ KQREEQAEAD GTESADKAAY LMGVNSGDLL KGLLHPRVRV GNEYVTKGQS
MEQVVFAVGA LAKATYDRLF RWLVSRINQT LDTKLPRQFF IGVLDIAGFE IFEFNSFEQL
CINFTNEKLQ QFFNQHMFVL EQEEYKREGI DWVFIDFGLD LQPCIDLIEK PLGILSILEE
ECMFPKASDA SFRAKLYDNH AGKSPNFQQP RPDKKRKYQA HFEVVHYAGV VPYSIVGWLE
KNKDPLNETV VPIFQKSQNK LLATLYENYA GSCSTEPPKS GVKEKRKKAA SFQTVSQLHK
ENLNKLMTNL RATQPHFVRC LVPNENKTPG VMDAFLVLHQ LRCNGVLEGI RICRQGFPNR
LLYADFRQRY RILNPSAIPD DTFMDSRKAT EKLLGSLDID HTQYQFGHTK VFFKAGLLGV
LEELRDQRLA KVLTLLQARG RGRLMRLEYQ RLLGGRDALF TIQWNIRAFN AVKNWSWMKL
FFKMKPLLRS AQAEEELAAL RAELRGLRGA LATAEAKRQE LEETHVSITQ EKNDLALQLQ
AEQDNLADAE ERCHLLIKSK VQLEGKVKEL SERLEDEEEV KNLTEEMAAL DESVARLTKD
KKALQEAHQQ VLGDLQAEED RVSALAKAKL RLEQQVEDLE CSLEQERKLR MDTERAKRKL
EGDLKLTQES VTDAAQDKQQ LEEKLKKKDS ELSQLNLRVE DEQLLGAQLQ KKIKELQARA
EELEEELEAE RAARARVEKQ RAEAARELEE LSERLEEAGG ASAGQREGCR KREAELGRLR
RELEEAALRH EATVAALRRK QAESAAELSE QVDSLQRVRQ KLEKEKSELR MEVDDLGTSV
ETLARGKASA EKLCRTYEDQ LSETKIKVEE LQRQLADTST QRGRLQTENG ELSRLLEEKE
SLISQLSRGK ASATQSLEEL RRQLEEESKA KNALAHAVQA LRHDCDLLRE QHEEEAEAQA
ELQRLLSKAN AEVAQWRSKY EADAIQRTEE LEEAKKKLAL RLQEAEEGVE AAHAKCSSLE
KAKLRLQTES EDVTLELERA TSAAAALDKK QRHLERALEE RRRQEEETQR ELEAAQREAR
SLGTELFRLR HSHEEALEAL ETFKRENKNL QEEISDLTDH VSLSGKSIQE LEKAKKALEG
EKSELQATLE EAEGALELEE TKTLRIQLEL SQVKAEVDRK LAEKDEECTN LRRNHQRAVE
SLQASLDAET RARNEALRLK KKMEGDLNDL ELQLGHATRQ ATEAQAATRL LQAQLKEEQA
GRDEEQRLAA ELREQAQALE RRGVLLATEL EELRAALEQG ERSRRLAEQE LLEATERLNL
LHSQNTGLLN QKKKLEVDLA QLSGEVEEAA QERREAEEKA KKAITDAAMM AEELKKEQDT
SAHLERMKKT LEQTVRELQA RLEEAEQAAL RGGKKQVQKL EAKVRELEAE LDAEQKKHAE
ALKGVRKHER RVKELAYQAE EDRKNLARMQ DLVEKLQSKV KSYKRQFEEA EQQANTNLAK
YRKAQHELDD AEERADIAET QANKLRARTR DALGPKHKE
//
