ID   L5LZ84_MYODS            Unreviewed;       720 AA.
AC   L5LZ84;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
DE   Flags: Fragment;
GN   ORFNames=MDA_GLEAN10023528 {ECO:0000313|EMBL:ELK31739.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK31739.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004369}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   EMBL; KB105949; ELK31739.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5LZ84; -.
DR   eggNOG; KOG1089; Eukaryota.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   CDD; cd14594; PTP-MTMR12; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR030576; MTMR12_PTP.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          178..616
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          522..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ELK31739.1"
SQ   SEQUENCE   720 AA;  83128 MW;  79F4462C730DD46C CRC64;
     EIHTNEKEAT EKEVTLHLLP GEQLLCEAST VLKCVQEDSC QRGIYGKLVC TDFKIAFLGD
     DESALESDET QFKNKIIGEN DIALHCVDQI YGVFDEKKKT LFGQLKKYPE KLIIHCKDLR
     VFHFCLRYTK EEEVKRIVSG IIHHTLAPKL LKRLFLFSYA SAVHSNTPTN PKNHTVMFDT
     LEDWCWELER TKGSMKYKAV SVNEGYKVCE RLPAYFVVPA PLPEETVSRF QGHGVPIWCW
     SYHNGCALLK MSALPREQDD GILQTHKNFL DGIYRVIHRP PYEIVKTEDL SSNFLSLPDI
     QTAYSKFKQL FLIDNSTEFW DTDIKWFSLL ESSSWLDIIR RCLKKAIEVI ECLDAQNTNV
     LLVEENASDL CCLVSSLVQV MMDPHCRTRA GFQSLVQKEW VAGGHCFLDR CNHLRQSDKE
     EVPVFLLFLD CVWQLVHQHP PAFEFTETYL TVLSDSLYIP IFTTFFFNSP HQKEMNLGRE
     GQDAHSTPLH LLTVWDWSVQ FESRAQTLLQ NPLYVEKPKL DKGQRKGTHL KHQRQLSLPL
     TQSKSSPKRG FFREETDHLI KNLLGKRISK LINYSDELQD SFREFYDSWH SKPADYHGLL
     LPHIEGPEVR VWAQRYLRWI PEAQILGGGA VAMTSRLVGM MEEVRSLQEK INERHHHQRA
     LPAEAPSLLR SSARLSSLFP FALLQRRPSK PVLPTSGWKA LGDEEDLARR EDEFVDLGEV
//