ID   L5M032_MYODS            Unreviewed;      1002 AA.
AC   L5M032;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Elastin microfibril interfacer 2 {ECO:0000313|EMBL:ELK31630.1};
GN   ORFNames=MDA_GLEAN10025289 {ECO:0000313|EMBL:ELK31630.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK31630.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB105967; ELK31630.1; -; Genomic_DNA.
DR   eggNOG; ENOG502QV5P; Eukaryota.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..42
FT                   /note="EMI"
FT                   /evidence="ECO:0000259|PROSITE:PS51041"
FT   DOMAIN          850..1001
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
FT   REGION          38..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          442..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          700..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          176..224
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          411..438
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        65..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..577
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..781
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1002 AA;  110084 MW;  8068F1C17179AF75 CRC64;
     MPCPSALVYR VNFRPRYVTR YKMVTQLEWR CCPGFRGADC QEGPRDPGKA LRPTPARPRS
     SLKKPTDNEP SQVSEPKKTL SPARASEPSQ AADPKLGPQE LQDKKIQVLE EKVHRLTRTV
     LDLQSSIAGV NENIKHTIQD DASKMLASWL NNLHPQPVPD SAVGRDTDTV QLPGDLNRTE
     SGMKDIKSEL AEVKDALKTK SDKLEELDGK VKGYEGQLKQ LQEAAQGPTV TMTTNELYQA
     YVDSKIEALR EELMEGMDRK LADLKNSCEY KLIGVQQPCD DYGSSYLGVI ELIGEKEANL
     KKEINDLRAR LQDPSARSNC CDGEKTGDFG QQIKVIEQKI ERVAEATRML NGRLDNEFDR
     LQVPEPDVDF DARWNELDAR INVTEKNAEE HCFYIEETLR GAINGEVDDL KQLLDQKIQS
     LEERXXXXXX RLGSLLLEMT NNTDAELTPP ASARPGGSGA GHDQVMVALN HLKKKVQVVE
     DMCLQGELHG IEDTLPNGED HTVGDSSSLL KSLNDTMHRK FQETERSIQK LQQDFSFLYS
     QLNHTEDAMN HLQNECKDTG VDGFPKGGER ERTVEPLPSP QDTEAPCCSQ LEERWQRLQS
     QVLAELDTCK DSTHGVQREV SVVEHRVSQM EKTCSKLDSI SGSLQRIKEG LNKHVGGLWG
     CVRQMNGTLR SHSRDISGLK NSVQQFYSHV FQISTDLQDL IKFQPPAGEE PSEAPPPPPR
     GKPPQLAEVP TEPSLPEPTP PPLPSAPPPP EDPGQQLPAG QQPLPPKGPQ QPLPWPAWPS
     WTGLPFLPGS TGVIMETGEA GPPGRMGVSG KGLPRGVDGQ MGQAPVPSAE GFAGAPGYSR
     SPPAASPGVP APSPVSFSAG LTQKPFPSDG GVVLFNKVLV NDGDMYDPST GIFTAPYDGR
     YLITATLTPE RDTYVEAVLS VSNASVAQLH TAGYKREFLE YHRPQGALHT CGGPGAFHLI
     VHLKAGDGVN IVVTGGRLAH TDFDEMYSTF SGFFLYPFLS HL
//