ID L5M036_MYODS Unreviewed; 745 AA.
AC L5M036;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Neuropilin and tolloid-like protein 1 {ECO:0000313|EMBL:ELK31682.1};
GN ORFNames=MDA_GLEAN10025350 {ECO:0000313|EMBL:ELK31682.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK31682.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; KB105967; ELK31682.1; -; Genomic_DNA.
DR AlphaFoldDB; L5M036; -.
DR eggNOG; ENOG502QUD4; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR24251:SF27; NEUROPILIN AND TOLLOID-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..745
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003970734"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..155
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 172..287
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 609..745
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT DISULFID 41..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 292..304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 299..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 311..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 745 AA; 83465 MW; 29242F4443E8150E CRC64;
MIYGRSVLHI VASLIILHLS GATKKGTEKQ ATSETQKSVQ CGTWTKHAEG GVFTSPNYPS
KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH IEVRDGPFGF SPIIGRFCGK
QSPPTIKSSG RFLWIKFFAD GELESMGFSA RYNFTPDPDF KDLGVLKPLP VCEFEMGGPE
GIVESIQIMK EGKASASEAV DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS
SSVEDLRAKF CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNMFFCH
SNMCINSTLV CNGLQNCVYP WDENHCKEKR KAGLLDQLTN TSGTVIGVTS CIVIILIIIS
VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG AGATADFADV GDDFDSYHKL
RRSSSKCIHD HHCGSQLSSA KGSRSNLSTR DASVLTEMPP QPVKPLVPPT NRRNILVMKH
NYSQDAADAC DIDEIEEVPT TSHRLSRHEK AVQRKLSHTC VWIETQTSAL FYEDVWKLVM
ACTRSAYGRV RWRFSCEDDP GLNHQSGGPR PEEAITEPIV LEGKCLVVCD SSPSADGAVT
SSLGISVRSG SAKVAFSATR STNHEPSEMS NRTMTIYFDQ VLVNIGNHFD LASSIFVAPR
KGIYSFSFHV VKVYNRQTIQ VSLMQNGYPV ISAFAGDQDV TREAASNGVL LLMEREDKVH
LKLERGNLMG GWKYSTFSGF LVFPL
//
