ID L5M0M7_MYODS Unreviewed; 4685 AA.
AC L5M0M7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Dynein beta chain, ciliary {ECO:0000313|EMBL:ELK31867.1};
GN ORFNames=MDA_GLEAN10018391 {ECO:0000313|EMBL:ELK31867.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK31867.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB105946; ELK31867.1; -; Genomic_DNA.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2610; -; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 2.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 2.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1797..1933
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2075..2266
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2462..2608
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2200..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..725
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3068..3137
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3368..3409
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4685 AA; 534348 MW; 415E3BD98CE65E5C CRC64;
MARLRHVSRC LTDQHCPLLL TPLLQNRLAQ AENRLMCMGH EVSITLYVVI PILVNGKNHV
DWPPVVCQDV QRHAHSLQCD LMVLLEQVRG KTLLPLPVGS ENMEFVDSEG ETILDSMDKS
VIYAIESAVI QWSRQVQAVL NKESSQPLFQ GENPTPWVEL EFWKSRSEDL EYIYDQLRTI
KVRGMAGLLD KLQSSYFPTF QAMCRDVTAA LMEAKDIHTH LMPLRRHLEA LEAVEFPEVK
PKLRPLLHVV CLIWATCKSY CSPGRLTVLL QEICNLLIQQ ASDYLSPEDL LKSEVEESQR
KLQVVVDTLN FFKQVFQDRR EDLHTYFKES QEVRAWDFQS SLVFVRLDGF LRHLLVVQDL
LKTTLDFHSL QKVEFSGIRG NALSQQVQQI DHEFQEMCRV FSESCHDCLD PQGMEFENDV
SKFNQRVEDL DRRLGTIFIQ AFDDAPDLEH AFKLLDIAGN LLERPLVAQD ASAKYLMLLQ
MFNKELDTVR TIYSQRVQEE AELGFSPVHK NMPSVAGGLR WAQELRQRIQ GPFANFRRIT
HPCMESAEGK RMIQKYEDVL SLLEKYESRL YEDWCQTVSK QSQYNLSRPL LTRDPATKQI
TVNFNPQLVS VLKEMSYLQP RQLQHIPETA AAMFSSREFY RQLVANLELM ANWYNKVMKT
LLEVEFPLVA GELRNIDLHL RVAEEALNWK SEGIWDYVIQ ITSSIRDLEK RIQKTKDNVE
EIQSIMKTWA SPVFKRKDGK KESLLSVDDQ HDRMEKYYSC IRESGLKIHA LVQENLDLFS
ADPTSDIWKT YVDYIDDMLL DGFFLAIECS LKYLLENTEC KAGLNPIFEA QLCLAVPELV
FSPSLEFGVK GGFYDMVEGL VTSIFRISSL VPRLSPQNSS PHYQADMEGL ADLARMRSVL
MERAQSMMAL CCSYRDTFSQ YSYLYVEDRR EILGQFLLYG HVPTPEEIEA HEEDGIPENP
PLLHQFQAQI DSYEQLYGEV CRLEPVKVFD SWMKIDVRPF KASLLNIIKR WSLMFKQHLV
DYVTNRGIRS QRQGQVRHIK VMEPAIQGPS LADLDVFIKN SEGSLLKKVE KGDSNGLVEI
MQHLMALKER QSSTDEMFEP LKQTIELLKT YEQELPETVF KQLEELPEKW NNIKKLAITV
RQHVAPLQAS EVALLRQRCT AFEAEQQQFW ERFHREAPFR FDSTNPHQSL DARHRELQEM
ESAMASISNS ASLFEVNVPD YRQLRQCRRE ICQLKELWDT IGMVTSNIRA WEATPWKSIS
VEAMDSECKR LARYLRNLDK EVRAWDAFTG LESMVLNTLT SLRAVAELQN PAIRERHWRQ
LMQATGVSFT MGEGTTLAQL LQLQLHRFED EVQGIVDRAV KEMGMEKTLK ELQATWAGME
FQYEPHLRTS VPLLRSDEDL IEVLEDNQVQ LQNLMMSKYI AFFLEDVSGW QKKLSTADAV
ISTWFDVQRT WSHLESIFIG SEDIRAQLPQ DSERFKGIDM DFKELAYDAQ KTPNVVEATN
KPGLYERLED IQSRLYLCEK ALAEYLDTKR LAFPRFYFLS SSDLLDILSN GTAPQQVQRH
LSKLFDNMAR MQFQLDASEQ PTKISLGMYS KEEEYVAFSE PCSCSGQVET WLNHVLAHMK
ATVRHEMTDG VTAYEEKPRE QWLFDYPAQV ALTCTQIWWT TEVGMAFARL EEGYESAMKD
YYKKQVAQLK ALITMLIGQL SKGDRQKVMT ICTIDVHARD VVAKMIAQKV DSAQAFLWLS
QLRHRWDDEA KHCFANICDA QFLYSYEYLG NTPRLVITPL TDRCYITLTQ SLHLTMSGAP
AGPAGTGKTE TTKDLGRALG IMVYVFNCSE QMDYKSCGNI YKGLAQTGAW GCFDEFNRIS
VEVLSVVAVQ VKSIQDAIRD KKKKFSFLGE EISLNPSVGI FITMNPGYAG RTELPENLKA
LFRPCAMVVP DFELICEIML VAEGFLEARS LARKFITLYQ LCKELLSKQD HYDWGLRAIK
SVLVVAGSLK RGDPDRPEDQ VLMRSLRDFN IPKIVTDDMP VFMGLIGDLF PTLDVPRRRD
LNFEALVRKA VVDLKLQAED NFVLKVVQLE ELLAVRHSVF VVGSAGAGKS QVLRSLHKTY
QIMKRRPIWT DLNPKAVTND ELFGIIHPAT REWKDGLFSS IMRELANVAH DGPKWILLDG
DIDPMWIESL NTVMDDNKQL LLAPLTALAL LAQQQWERGC RQTEDPGLQQ EGPERGMEDG
PRPTLVPTAA LQPTVPFKVL TLASNERIPL NPTMRLLFEI SHLRTATPAT VSRAGILYIN
LADLGWSPPV SSWIEKREIQ TERANLTILF DKYLPTCLDT LRTRFKRIIP IPEQSMVQTL
CHLLECFLAE ENIPADCPKD TYELYFVFAA IWAFGGAMIQ DQLVDYRAEF SKWWLAEFKT
IKFPSQGTIF DYYIDPETKK FEPWSTLIPQ FEFDPEMPLQ ACLVHTSETI RLCYFMERLL
QRRRPLMLVG TAGTGKSVLV GAKLASLDAE EYLVKNVPFN YYTTSVMLQA ALEKPLEKKA
GRNYGPPGHK KLIYFIDDMN MPEVDAYGTV QPHTLIRQHL DYGHWYDRNK LSLKEITNVQ
YVSCMNPTSG SFTINPRLQR HFSVFVLSFP GADALSSIYS SILTQHLRLG NFPASLQKST
PQLINLALTF HQKVATTFLP TAIKFHYIFN LRDFANIFQG ILFSSVECVK SARDLVKLYL
HESNRVYRDK MVEEKDFVLF DKIQTEVVKK IFDDMEETVE QTGSLSMYCH FANGIGEPKY
MPVQSWELLT QTLAEALENH NEVNAVMDLV LFEDAMRHVC RINRILESPR GNALLVGVGG
NGKQSLTRLA AFISSMDVFQ ITLRKGYQIL DFKMDLAGLC LKAGVKNIST VFLMTDAQVA
DEKFLVLIND LLASGEVPDL YSDDEVESII SNVRNEVKSQ GLVDNRENCW KFFIDRVRRQ
LKVTLCFSPV GNKLRVRSRR FPAIVTCTAI DWFHEWPQQA LESVSLRFLQ STESIEPTVK
QSISKFMAFV HTSVNQTSQS YLSNEQRYNY TTPKSFLEFI RLYQSLLRRN GQELKSKTER
LENGLLKLHS TSAQVDDLKA KLATQEVELK QKNEDADKLI QEVGIETDKV SREKAMADEE
ERKVALIMLE VQQKQRDCEE DLAKAEPALT AAQAALNTLN KTNPQRLSKA QAGRGWQLPL
PGPKAHGCPS GQTCSRYPRL RQATDGSCHC QGPRLRQRGP GKGSGKLWWL QSLRLRQALQ
LTNLTELKSF GSPPPAVSNV SAAVMALMAP GGKVPKDRSW KAAKVAMARV DGFLDSLVRF
DKENIHQNCL RAIRPYLQDP EFNPEFVATK SYAAAGLCSW VINIVKFYEV FCDVEPKRQA
LGRATSDLTT AQEKLAAIKA KIAHLDENLA KLTAKFERAT ADKLKCQQEA EATAGTISLA
NRLVGGLASE NVRWAEAVQN FKQQESTLCG DILLITAFIS YLGFFTKKYR QSLMDGTWRP
YLSQLQVPIP VTPGLDPLRM LTDDADVAAW QNQGLPADRM SVENATILVT CERWPLLVDP
QLQGIKWVKN KYGEDLRVTQ IGRKGYLQTI EQALEAGHVV LIENLEESID PVLGPLLGRE
VIKKGRFIKI GDKECEYNPK FRLILHTKLA NPHYQPELQA QATLINFTVT RDGLEDQLLA
AVVSMERPDL EQLKPFCSRF LKIGDKECEY NPKFRLILHT KLANPHYQPE LQAQATLINF
TVTRDGLEDQ LLAAVVSMER PDLEQLKSDL TKQQNGFKIT LKTLEDSLLS RLSSASGNFL
GDTALVENLE VTKQTAAEVE EKVQEAKVTE VKINEAREHY RPVAARASLL YFIMNDLSRI
HPMYQFSLKA FSSVFQRAVE KAAPHESLPQ RVASLMDSIT FSVFQYTTRG LFECDKLTYL
AQLTFQILLL NQAVGAAELD FLLRSPVQAG VTSPVEFLSH QAWGGIKALS AMEEFCNLDR
DIEGSAKSWK KFVESECPEK EKFPQEWKSK TALQRLCMMR AMRPDRMTYA MRHFVEETLG
SKYVVGRALD FATSFEESGP ATPIFFILSP GVDPLKDVEN QGKKLGYTFN NRNFHNVSLG
QGQEVVAEAA LDLAAKKGHW VILQNIHLVA KWLGTLEKKL EELSASSHPE FRVFISAEPA
PSPEGHVIPQ GILENSIKIT NEPPTGMHAN LHKALDNFTQ DTLETCSREA EFKSILFALC
YFHAVVAERR KFGPQGWNRS YPFNTGDLTI SVHVLYNFLE ANAKVPYDDL RYLFGEIMYG
GHITDDWDRR LCRTYLEEFI KPEMLEGELT LAPGFPLPGN MDYNGYHEYI DAELPPESPY
LYGLHPNAEI GFLTQTSEKL FRTVLELQPR DSHGGDGAAA TREEKVKALL EEILERVTDE
FNILELMARV EERTPYIVVA LQECERMNTL TSEIRRSLRE LHLGLKVRED LGGKGVASWA
PLRRKWDRGS WELETSSPAA IQMPKRVSPQ KLESAHAAGR GELTMTSDME NLENNLYLDT
VPEPWARRAY PSTAGLSVWF LDLLSRIKEL EAWVGDFAMP STVWLTGFFN PQSFLTAIMQ
SMARKNEWPL DQMALQCDVT KKNREDFRSP PREGAYVHGL FMEGARWDAQ AGVITEAKLK
DLTPPMPVMF IKAIPADKQD GRSVYACPVY KTCQRGHTYV WTFNLKTKEN PSKWVLAGVA
LLLQV
//