ID L5M2R0_MYODS Unreviewed; 910 AA.
AC L5M2R0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0000313|EMBL:ELK32671.1};
GN ORFNames=MDA_GLEAN10026164 {ECO:0000313|EMBL:ELK32671.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK32671.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB105166; ELK32671.1; -; Genomic_DNA.
DR AlphaFoldDB; L5M2R0; -.
DR eggNOG; KOG3531; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 1..217
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 429..620
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 649..746
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 823..910
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 257..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 269..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 103586 MW; A833C9FAD1E4A51A CRC64;
MNAFPTLPNT CIQTLSSANP MDKTWNFSFI FLFLLEAQSM NSCTGPKNTM LRLAVKFFPP
DPAEIGDYDE TLDREHLKVN KYLPHQECCL EKILEFHRKH MGQTPAESDF QVLEVARKLE
MYGIRFHKAS DREGAKINLA VSHMGVLVFQ CTTKINTFNW SRVRKLSFKR KRFLIKLHPE
VHGPYQDTLE FLLGSRDECK NFWKICVEYH TFFRLFDQPK PKAKAVLFSR GSSFRYSGRT
QKQLVDYVKD GVMTRTSYER KHSRTRTSGH ALTTELPKQS ISFTEGMRTS ASPSSTHASF
YSVPTSPVAP PGRPNIKDSI ISLTEPQAPH TKRPAAERTC EALEGPDMRQ AQPPGPPAVQ
PCQGLPMDSP QPSPSTQKSP LSLSPVFQVT LGPAERGSFP LLSPVLSDAG GTRMDDEEEP
KHKGTGADEA YFIAKEILAT ERTYLKDLEV ITVWFRSAVV KEDAMPADLM TLLFSNIDPI
YEFHRGFLCE VEQRLALWEG PSGAQAPGSH QRIGDVLLRN MRQLKQFTGC FQRHDEVLTE
LEKATKRFKK LETVYREFEL QKVCYLPLNT FLLKPIQRLV HYRLLLRRLC GHYAPGHHDY
PDCCDALQVI TEVTSVLQHS LVRLENLQKL TELQRDLVGI ENLIAPGREF IREGCLHKLT
RKGLQQRMFF LFSDMLLYTS RGVSGTSHFR IRGLLPLRGM LVEESKSEWS VPHCFTIYAA
QKTIVVAAST QLEKEKWMHD LKNAIEAAKS SGNMTLALPG SAVCIPPRRP SDEVSLEQES
EDDAHGPHSS SEGPGQHRAN TTVHVCWYRN TSVSRADHSA AVENQLSGYL LRKFKNSNGW
QKLWVVFTNF CLFFYKTHQD DYPLASLPLL GYSVSIPREA DGIHKEHVFK LQFKSHVYFF
RAESKYTFGR
//
