ID L5M4P0_MYODS Unreviewed; 901 AA.
AC L5M4P0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Toll-like receptor 6 {ECO:0000313|EMBL:ELK33594.1};
GN ORFNames=MDA_GLEAN10018651 {ECO:0000313|EMBL:ELK33594.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33594.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KB104013; ELK33594.1; -; Genomic_DNA.
DR AlphaFoldDB; L5M4P0; -.
DR eggNOG; KOG4641; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR029374; TMEM156.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF15106; TMEM156; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK33594.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 745..886
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 901 AA; 103262 MW; 7752CEB9D16E50BB CRC64;
MMGIFLNHSS VQNFTRICPD ITSEFQMCSS CLVCESKGNM DFISQEQTPK VLIMRGSMEV
KANDLSPCRH FNFTVAPAVD HSEEYNITCN LKTGTRTSAM MEEEPTTEKS IDHTCGIMNH
SHNCVHISLH LEMDVKRAKQ RLPSTQVKVV LSPIPELEVP SPTHQRVYTD LDAYQDALKN
SDSPSGDSRF NIMTKDKEPI VRSFHFVCMI TLIFGTIIQF SAESEFAVNE SNKGLAHVPK
GLPPKTIVLD MSQNYISELH LSDISFLSGL RVLRLSHNRL QYLDISIFKF NQDLEYLDLS
HNQLQKLSCH AVTSLKHLDL SFNDFDALPI CEEFGNLTQL TFLGLSAKHL QQLDLLPVAH
LHLTGILLEL EGYYVKEHET ESLQILNTKT LHLVFHPNNF FSVQANISVS NVGCLQLSNI
RLKDENCHVL ITFLSELTRG PNLLNITFNH VETTWKCLVR VFQFLWPKPV EYLNIYNATI
VEKIDKEDFT YSETSLKGLK IEHITNKVFL FSQTVLYTLL SEMNIMMLTI SDTPFIHMLC
PQAPSTFKFL NFTQNVFTDS IFQECSTLVR LETLILQKNE LKDLFKVGLM TKDMPSLEML
DVSWNSLEYD GRNRNCTWAE HIEVLNLSSN ILTDSVFRCL PPRLRVLDLH SNRITSIPEN
VIRLEVLQEL NVASNSLAHL PGCDSFSSLS VLIIDYNSIS NPSAHFFQSC QKIRSINAGI
RMGGQWTQTR HRARNTSLHE LQRTLQFHAF ISYSEHDSAW VKNELLPNLE KEDIRICLHE
RNFVPGKSIV ENIINCIEKS YKSIFVLSPN FVQSEWCHYE LYFAHHNLFH EGSNNLILIL
LDPIPQNSIP SKYHKLKALM AQRTYLEWPK EKSKHGLFWA NIRAAFNVKL TLTTENNDVK
T
//
