ID   L5M5T9_MYODS            Unreviewed;       939 AA.
AC   L5M5T9;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Septin-8 {ECO:0000256|ARBA:ARBA00023867};
GN   ORFNames=MDA_GLEAN10009167 {ECO:0000313|EMBL:ELK33702.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33702.1, ECO:0000313|Proteomes:UP000010556};
RN   [1] {ECO:0000313|Proteomes:UP000010556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000256|ARBA:ARBA00004432}. Presynapse
CC       {ECO:0000256|ARBA:ARBA00034106}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family.
CC       {ECO:0000256|RuleBase:RU004560}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB103926; ELK33702.1; -; Genomic_DNA.
DR   eggNOG; KOG3859; Eukaryota.
DR   Proteomes; UP000010556; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016491; Septin.
DR   PANTHER; PTHR18884; SEPTIN; 1.
DR   PANTHER; PTHR18884:SF54; SEPTIN-8; 1.
DR   Pfam; PF00735; Septin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT   DOMAIN          538..804
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51719"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..939
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          820..905
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   939 AA;  104311 MW;  9684E52FF125C6A4 CRC64;
     MEALGPGGDR VSPASSTRXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXAGECWGGA CSGFGFARRE TQGLQHQAVA AFEGLQIRWL
     RGTEHREPLS LKLHDDVYRP AGRSQSASGE ALGAWGGPGG AVPILQAVPQ GAEPRALFQT
     THSRFLTQKE AAVVCPAEGP QSRPIDCELR VPETHIVCAR LPSLPDDDVF LEEVPLVRMR
     APPDSPAPPR LPASVHASDS QPGAGLGQRP GRATVSPEHP LPECVESAGT DDCWPTCCGS
     PGTANGDVPT HDCTGLLTTD FPAAVERDSL KPLPVDALGP PGSDTQGPPD DTAWAWGPVQ
     PDSKPTWPSP RLEQLVQELA RLDPSLSDTL TSYPSPEPPL DLLDGLIPLA EVWAAMRPAG
     GKAGEEAAGI SEPGETEYIV PPYETQQNAE PEPRSLSLGG HVGFDSLPDQ LVSKSVTQGF
     SFNILCVGET GIGKSTLMNT LFNTTFETEE ASHHEECVRL RPQTYDLQES NVHLKLTIVD
     AVGFGDQINK DESYRPIVDY IDAQFENYLQ EELKIRRSLF DYHDTRIHVC LYFITPTGHS
     LKSLDLVTMK KLDSKVNIIP IIAKADTISK SELHKFKIKI MGELVSNGVQ IYQFPTDDEA
     VAEINAVMNA HLPFAVVGST EEVKVGNKLV RARQYPWGVV QVENENHCDF VKLREMLIRV
     NMEDLREQTH SRHYELYRRC KLEEMGFQDS DGDSQPFSLQ ETYEAKRKEF LSELQRKEEE
     MRQMFVNKVK ETELELKEKE RELHEKFEHL KRVHQEEKRK VEEKRRELEE ETNAFNRRKA
     AVEALQSQAL HTTLQQPLRK DKDKKKASGW SSIYSVTIP
//