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Database: UniProt
Entry: L5ME41_MYODS
LinkDB: L5ME41_MYODS
Original site: L5ME41_MYODS 
ID   L5ME41_MYODS            Unreviewed;      2305 AA.
AC   L5ME41;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   05-JUN-2019, entry version 49.
DE   RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE            EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN   ORFNames=MDA_GLEAN10014828 {ECO:0000313|EMBL:ELK36646.1};
OS   Myotis davidii (David's myotis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK36646.1};
RN   [1] {ECO:0000313|EMBL:ELK36646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:ELK36646.1};
RA   Zhang G., Cowled C., Wang L.;
RT   "Comparative analysis of bat genomes provides insight into the
RT   evolution of flight and immunity.";
RL   Science 0:0-0(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a
CC         1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;
CC         Evidence={ECO:0000256|RuleBase:RU361133};
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DR   EMBL; KB101390; ELK36646.1; -; Genomic_DNA.
DR   STRING; 225400.XP_006755144.1; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.150; -; 1.
DR   Gene3D; 3.20.20.190; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR028398; PLC-epsilon1.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR015359; PLC_EF-hand-like.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10336; PTHR10336; 1.
DR   PANTHER; PTHR10336:SF6; PTHR10336:SF6; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF09279; EF-hand_like; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   Pfam; PF00387; PI-PLC-Y; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00390; PHPHLIPASEC.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SMART; SM00149; PLCYc; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168}; Hydrolase {ECO:0000256|RuleBase:RU361133};
KW   Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW   Transducer {ECO:0000256|SAAS:SAAS01019513}.
FT   DOMAIN      528    781       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN     1662   1798       PI-PLC Y-box. {ECO:0000259|PROSITE:
FT                                PS50008}.
FT   DOMAIN     1813   1897       C2. {ECO:0000259|PROSITE:PS50004}.
FT   DOMAIN     2141   2244       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION        1     75       Disordered. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   REGION      778    798       Disordered. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   REGION     1050   1189       Disordered. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   REGION     1563   1588       Disordered. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   REGION     2266   2305       Disordered. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   COMPBIAS     15     75       Polar. {ECO:0000256|MobiDB-lite:L5ME41}.
FT   COMPBIAS   1054   1079       Polar. {ECO:0000256|MobiDB-lite:L5ME41}.
FT   COMPBIAS   1086   1117       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                L5ME41}.
FT   COMPBIAS   1118   1189       Polar. {ECO:0000256|MobiDB-lite:L5ME41}.
FT   COMPBIAS   2266   2293       Polar. {ECO:0000256|MobiDB-lite:L5ME41}.
SQ   SEQUENCE   2305 AA;  257732 MW;  4F8169A30CCDC596 CRC64;
     MTSEEMAASD LIPVTQRKVV SSQSAADESS EKASGVSVPK THTPGQSRST SHTISKLNKP
     KEETSGSNLP RIFSTTRGEI MSDENSNETC WEKNMPDSVK NLNVNGNNIL ENRQCGLPQS
     QFYKTCDSVV EEGLHLETGI SSSLERKVFP GIQLELDGPP MGIRPLGNQS ATSRAHPDSD
     LAVFHFHYEL DRRMSDSVCT LSDNLILDDC GNCVSLPDVG REQKKNYMAY TCKLMELAKS
     CDHENKQLQG DHCDALNDEY MCCEASCQKA NVVCSSDSFC REGFTDSPSA ETFLSHFEDF
     PDNCEDVEDD FKSKKERSTL LVRRFCKNDR EVKKSVYTGT RAIVRTLPSG HIGLAAWSYI
     DMKRSGSLLP CGRVTGQLST VLVRQDVSPC LSEAQWYPIY NAVRRGEETE DTIGSLLHFF
     TKLPASETAY ERINVGPCLK QCVQDTACEY RATLQRTSIS QYITGSLLEA TTSLGARSGL
     LSTFGGSTGR MMLKERQPGT SMANSSALPS SSAGISKELI DLQPLIQFPE EVASILMEQE
     QNIYRRVLPV DYLCFLTQNL STPECQRSLP CLKASISASI LNSQNREHNA LEDLVMRFNE
     VSSWVTWLIL TAGSMEEKRE VFSYLVHVAK CCWNMGNYNT VMEFLAGLRS RKVLKMWQFM
     DQSDLETMRS LKDAMAQHES SCEYRKVVTR ALHIPGCRVV PFCGVFLKEL CEVLDGASGL
     VKLCPRYNAQ EETLEFVADY SGQDNFLQRV GQNGLKNSEK ESTVNSIFQI IRSCSRSLEA
     EDEDSPSEGS GSRKNSLKDK APRCQFVIGD LLDTENDIFE QPKEWDPHGL EEPQKAFDHG
     IELIPWYVLS IRADVHQFLL QGATVIHYDQ DTHLSARCFL QLQPDNSTLT WIKPTTASPA
     SAKAKLGMPT ATSEPGKFPL LGNAGLSGLA EGVLDLFSVK AVYMGHPSID IHTVCVQNKL
     SSMFLSETGV TLLYGLQTTD NRLLHFVAPK HTAKMLFSGL LELTKAVRKM RKFPDQRQQW
     LRKQYVSLYQ EDGRYEGPTL AHAVELFGGR RWSTRNPSPG TSAKSAEKPN MQRNNTLGIG
     TAKKKKKILM RGESGEATDD EMATRKAKLH KECRSWSGSD PQDINEQEES EANAITSPPN
     PLPSRRAHSL TTAGSPILAP GTSSPIRPVS SPVLSSNKSP SSAWSSSSWH GRIKGGMKGF
     QSFMVSDSNM SFVEFVELFK SFSVRSRKDL KDLFDLYAVP CNRSGSESAP LYTNLTIDEN
     TSGLQPDLDL LTRNVSDLGL FIKSKQQLSD NQRQISDAIA AASIVTNGTG VESTSLGVFG
     VGILQLNDFL VNCQGEHCTY DEILSIIQKF EPSISMCHQG LMSFEGFARF LMDKDNFASK
     NDESQENIKE LQLPLSYYYI ESSHNTYLTG HQLKGESSVE LYSQVLLQGC RSVELDCWDG
     DDGMPIIYHG HTLTTKIPFK DVIEAIDRSA FINSDLPIII SIENHCSLPQ QRKMADIFKT
     VFGEKLVAKF LFESDFSDDP MLPSPDQLRR KVLLKNKKLK AHQTPVDILK QKAHQLASMQ
     AQAYNGGNVN PPPTNNEEEE DEEDEYDYDY ESLSDDNILE DRPESKSCSD KLQFEYNEEI
     PKRIKKADNS ACNKGKVYDM ELGEEFYLPQ NKKESRQIAP ELSDLVIYCQ AVKFPGSCEG
     MRQAWEESSS PLSPATSLSA IIRTPKCYHI SSLNENAAKR LCRRYSQKLI QHTACQLLRT
     YPAATRIDSS NPNPLMFWLH GIQLVALNYQ TDDLPLHLNA AMFEANGGCG YVLKPPVLWD
     KNCPMYQKFS PLERDLDNME PAVYSLTIVS GQNVCPSNST GSPCIEVDIL GMPLDSCHFR
     TKPIHRNTLN PMWNEQFFFR VHFEDLIFLR FAVVENNSSA VTAQRIIPLK ALKRGYRHLQ
     LRNLHNEVLE ISSLFVNSRR MEEISSGSSV PASLCVAKVK NSTLAKVEGG IACLVQRTGN
     QGLGCLAPKS KNQMLSEGKA GLPAQSQMFS TEERKCLQTH RVTVHGVPGP EPFTVFSING
     STKAKQLLQQ ILTTEQDTKP IAADYFLMEE KYFISKEKNE CRKQPFQRAI GPEEEIVQIL
     SSWFPEEGYV GRIVLKTQQE NLEEKSIVQD DREVILSSEE ESFFVQVHDV SPEQPRTVIK
     APRVSTAQDV IQQTLCKAKY SYSILSNPNP NDYVLLEEVV KDTANKKSST PKSSQRVLLD
     QECVFQAQSK WKGAGKFILK LKEQVQASRE DKRKGISFAS EFKKFTKSTK QPRGLTSPSQ
     VLVSESVQNK EERPVGGSDT MDYRQ
//
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