ID L5MHD2_MYODS Unreviewed; 596 AA.
AC L5MHD2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Ligand of Numb protein X 2 {ECO:0000313|EMBL:ELK37722.1};
GN ORFNames=MDA_GLEAN10008284 {ECO:0000313|EMBL:ELK37722.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK37722.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB100096; ELK37722.1; -; Genomic_DNA.
DR AlphaFoldDB; L5MHD2; -.
DR eggNOG; KOG3528; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF33; LIGAND OF NUMB PROTEIN X 2; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 49..87
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 232..329
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 374..460
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 506..588
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 326..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 65463 MW; E56BE7A0DBFB05B7 CRC64;
MGTTSDEMVS VEHTSSSFNP LCFECGQQHW TRENHLYNYQ NEVDDDLVCH ICLQPLLQPL
DTPCGHTFCC KCLRNFLQEK DFCPLDRKRL HFKLCKKSSI LVHKLLDKLL VACPFSSVCQ
DVMQRCDLEA HLKNRCPGAS HQRIALERRK TSKTQTEIEN ENGTTVIDLP STLSPETDCS
GTGTVPAERN LTSASLPVWT EEPGLDNPAF EESTIADTTQ QPPSLPEGEI TTIEIHRSNP
YIQLGISIVG GNETPLINIV IQEVYRDGII ARDGRLLAGD QILQEGRLSS NDRVLAINGH
DLKHGTPELA AQIIQASGER VNLTIARPGK PPPGNTIREA GTQSSSQHHA QPLYYSRPSS
HKDLTQCVTC QEKHITVKKE PHESLGMTVA GGRGSKSGEL PIFVTSVPPH GCLARDGRIK
RGDVLLNING IDLTNLSHSE AVAMLKASAA SPAVALKALE VQVVEEATQA TDEQPSTFSE
NEYDASWSPS WIMWLGLPSS LHSCHDIVLR RSYLGSWGFS IVGGYEENHT NQPFFIKTIV
LGTPAYYDGR LKCGDMIVAV NGLSTVGMSH SALVPMLKEQ RNKVTLTVIC WPGSLV
//
