ID L5MJG7_MYODS Unreviewed; 1531 AA.
AC L5MJG7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:ELK38430.1};
GN ORFNames=MDA_GLEAN10011655 {ECO:0000313|EMBL:ELK38430.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK38430.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB098936; ELK38430.1; -; Genomic_DNA.
DR eggNOG; KOG2301; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..965
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1180..1200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1247..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1282..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1369..1393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..466
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 527..683
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 947..1022
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1056..1132
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1178..1403
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 206..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 877..906
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1531 AA; 175875 MW; C8B2BB177B08E7EF CRC64;
MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT
FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKVFE IADIVDQMSP WGMLRIPRPL
IMIRAFRIYF RFELPRTRIT NILKRSGEQI WSVSIFLLFF LLLYGILGVQ MFGTFTYHCV
VNDTRRGGSL RCSPVQSDWG WVEARHPALP NPGRSTPSEL SPTWKGHGSR SWDHGQPQVL
PPARQGHRSV SWSRGQPQAL SPTCQVMDLG PRPWTASSTA PRLPGSQIRS PTADSFSRCH
LTLVCKLAAI LLLQERKGEG KRDRNINDDR ESLIGCLLHT PYWGLSPQSR NVTWNSLAIP
DTHCSPELEE GYQCPPGFTC MDLEDLGLSR QELGYSGFNE IGTSIFTVYE AASQEGWVFL
MYRAIDSFPR WRSYFYFITL IFFLAWLVKN VFIAVIIETF AEIRVQFQQM WGSRSSTTST
ATTQMFHEDA AGGWQLVAVD VNKPQGRAPA CLQQMMRSSV FHMFILSMVT VDVIVAASNY
HKGESFRRQY DEFYLAEVLR VVRLIKISPA LEDFVYKIFG PGKKLGSLVV FTASLLIVMS
AISLQMFCFV EELDRFTTFP RAFMSMFQIL TQEGWVDVMD QTLNAVGTMW APVVAIYFIL
YHLFATLILL SLFVAVILDN LELDEDLKKL KQLKQSEANA DTKEKLPLRL RIFEKFPNRP
QMVKISKLPS DFTVPKIRES FMKQFIDRQQ QDTCCLLRSL PSASSSSCDH SKRSAIEDNK
YIDQKLRKSV FSIRARNLLE KETAVTKILR ACTRQRMLSG SFEGQPAKER SILSVQHHIR
QERRSLRHGS NSQRISRGKS LETLTQDHSN TVRYRNAQRE DSEIKMIQEK KEQAEMKRKV
QEEELRENHP YFDKPLFIVG REHRFRNFCR VVVRARFNAD LLGLVTYLDW VMIIVTICSC
ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF
IYLEDCNGIF RINVSVSKNL NLKLRPGEKK PGFWVPRVWA NPRNFNFDNV GNAMLALFEV
LSLKGWVEVR DVIIHRVGPM HGIYIHVFVF LGCMIGLTLF VGVVIANFNE NKGTALLTVD
QRRWEDLKSR LKIAQPLHLP PRPDNDGFRA KMYDITQHPF FKRTIALLVL AQSVLLSVKW
DVEDPVTVPL ATMSVVFTFI FVLEVTMKII AMSPAGFWQS RRNRYDLLVT SLGIVWVVLH
FALLVTLKML LLTVVVSMYK SFFIIVGMFL LLLCYAFAGV VLFGTVKYGE NINRHANFSS
AGKAITVLFR IVTGEDWNKI MHDCMVQPPF CTPDEFTYWA TDCGNYAGAL MYFCSFYVII
AYIMLNLLVA IIVENFSLFY STEEDQLLSY NDLRHFQIIW NMVDDKREGV IPTFRVKFLL
RLLRGRLEVD LDKDKLLFKH MCYEMERLHN GGDVTFHDVL RXXXXXXXXX XXXXXXXXXX
XXXXXGAQLC APELNRVETE AVTMKGLMKC N
//
