ID L7FK60_9ACTN Unreviewed; 562 AA.
AC L7FK60;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:ELP71065.1};
GN ORFNames=STRTUCAR8_06574 {ECO:0000313|EMBL:ELP71065.1};
OS Streptomyces turgidiscabies Car8.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698760 {ECO:0000313|EMBL:ELP71065.1, ECO:0000313|Proteomes:UP000010931};
RN [1] {ECO:0000313|EMBL:ELP71065.1, ECO:0000313|Proteomes:UP000010931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Car8 {ECO:0000313|EMBL:ELP71065.1,
RC ECO:0000313|Proteomes:UP000010931};
RX PubMed=21087627; DOI=10.1016/j.plasmid.2010.11.002;
RA Huguet-Tapia J.C., Badger J.H., Loria R., Pettis G.S.;
RT "Streptomyces turgidiscabies Car8 contains a modular pathogenicity island
RT that shares virulence genes with other actinobacterial plant pathogens.";
RL Plasmid 65:118-124(2011).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELP71065.1}.
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DR EMBL; AEJB01000019; ELP71065.1; -; Genomic_DNA.
DR RefSeq; WP_006373596.1; NZ_AEJB01000019.1.
DR AlphaFoldDB; L7FK60; -.
DR STRING; 85558.T45_02440; -.
DR PATRIC; fig|698760.3.peg.306; -.
DR Proteomes; UP000010931; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010931};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..181
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 286..558
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 562 AA; 57780 MW; D26DCDC18235E08A CRC64;
MGNRRRVAER RSARKTRPAV IGGMIAVVVG GAGFGGYALY GGGAAAEDGS STAATADRKP
SVPTGPVPAK QVRAIATQFL TSWQTGKVAA AAASTNDTTA SATNLLTGYT KDAHITGVTI
TPGTATGAKV PFTVKGTVKY GGTSKPLTYE SALTVVRRTS DGKPLVDWHA SVIHPDLADG
DKLLTGESGT PPIKAVDRDG GELTLAKYPS LGTVLDSLRE KYGKKAGGKA GIELRVVRGK
ESKAAKAADK TLLELSKGTP GTVKTTLSPA LQTAAEAQVL KKPKSSVVLL RPSTGEILAV
ANQSHGFNTA FQGSLAPGST MKVITSSLLI EKDLASPDKP HPCPKFSTYG GWKFQNDDKF
EIKGGTFKAS FARSCNTAFI SQAPKLDNDS LTKQAQQVFG LGMDNWAIGV STFDGSVPVQ
SQAQMAASLI GQGGVRMNPL NMASVAATVG SGVFHQPYLV SPEVDGRTLA TAARTMSSST
LSQLRELMQY TAAYGTAAEA MSGLGPNYGA KTGSAEVDGQ DKPNGWFTAY RGDLAGAGVV
VEGGHGGSTA GPIVAALLRA GS
//
