ID L7FL06_ENTIV Unreviewed; 568 AA.
AC L7FL06;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Tyrosine protein kinase SRK3, putative {ECO:0000313|EMBL:ELP86019.1};
DE EC=2.7.11.25 {ECO:0000313|EMBL:ELP86019.1};
GN ORFNames=EIN_235360 {ECO:0000313|EMBL:ELP86019.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP86019.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP86019.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP86019.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB207020; ELP86019.1; -; Genomic_DNA.
DR RefSeq; XP_004185365.1; XM_004185317.1.
DR AlphaFoldDB; L7FL06; -.
DR EnsemblProtists; ELP86019; ELP86019; EIN_235360.
DR GeneID; 14884981; -.
DR KEGG; eiv:EIN_235360; -.
DR VEuPathDB; AmoebaDB:EIN_235360; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 1.
DR CDD; cd13999; STKc_MAP3K-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR45756; PALMITOYLTRANSFERASE; 1.
DR PANTHER; PTHR45756:SF1; SERINE_THREONINE-PROTEIN KINASE DDB_G0278665-RELATED; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:ELP86019.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:ELP86019.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 126..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..568
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 426
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 332
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 431
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 449
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 568 AA; 64853 MW; 65D7D812A5450610 CRC64;
MGVINAKTSI IESVWTVFHN NIGLCLPQSS ITGCAVNTTQ FGCSKCQDEF LTSNLYECEK
CNENCTKCTS QNQCTSCVNN KILFENGLCF DISFVKKCTE IFNSKCSKCA FWYSPTNSGT
SCNKKVVWWV ILIVIILILI VISIVVLIIY FIVSKIQRKC LQRETKKTTT LFKMSRSNIS
FISLGNGIVV NKKEIDFGDD IAVNEKQREL LCVGNTTKYN TKIQITTKSE NVTKYKFETQ
PNVIVLGKDD ACEFEIFIEL KCTTKLNERL MLVAKMGVTH KNLIKEVKIK ATSKLSTRLD
PDELTEEKIL GEGSFGVVYK GVFRGNKVAI KKMKNSEDMN EENDEFTKEV AMLDKFRSEY
IVYFYGAVFI PSKVCMVTEY APFGSLQDLM KHKTSDEIDI KIRIKMMTDA AKGISYLHEN
GILHRDIKPD NLLVFLLDLN DKVNAKLTDF GSARNVNLMM TNMTFTKGIG TPVYMALEVL
NREKYTKSAD VYSFGVTMYE VFGWAEAYPI NTFKFPWKIA EYVTAGKRPE KRKNIPDVWF
EFIKMCWKQN PKERNSITKV VECIQNIE
//
