ID L7JS70_TRAHO Unreviewed; 847 AA.
AC L7JS70;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Chaperone HSP104, ATP-dependent Clp protease {ECO:0000313|EMBL:ELQ74264.1};
DE EC=3.4.21.53 {ECO:0000313|EMBL:ELQ74264.1};
GN ORFNames=THOM_2803 {ECO:0000313|EMBL:ELQ74264.1};
OS Trachipleistophora hominis (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Trachipleistophora.
OX NCBI_TaxID=72359 {ECO:0000313|EMBL:ELQ74264.1, ECO:0000313|Proteomes:UP000011185};
RN [1] {ECO:0000313|EMBL:ELQ74264.1, ECO:0000313|Proteomes:UP000011185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA Embley T.M.;
RT "The genome of the obligate intracellular parasite Trachipleistophora
RT hominis: new insights into microsporidian genome dynamics and reductive
RT evolution.";
RL PLoS Pathog. 8:E1002979-E1002979(2012).
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DR EMBL; JH994055; ELQ74264.1; -; Genomic_DNA.
DR AlphaFoldDB; L7JS70; -.
DR STRING; 72359.L7JS70; -.
DR VEuPathDB; MicrosporidiaDB:THOM_2803; -.
DR HOGENOM; CLU_005070_4_1_1; -.
DR InParanoid; L7JS70; -.
DR OMA; GRVIQEH; -.
DR Proteomes; UP000011185; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF190; CLP R DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:ELQ74264.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:ELQ74264.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011185};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 170..309
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 578..734
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 741..823
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 408..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 94662 MW; A613C66FA49F6751 CRC64;
MSTGFTSTAQ KVLERSFSTA KKFKNYQIEP EHLLLALMES DIPVLEKNLT REEKSRMKTE
LIRRIDTLAK GNESTTPNPS SRFTNMLQDA QGNKEGVSEI DLLGAAIKCV QIEGTKKLEA
VVRTVSESKT PTLDSVAVEM VHEARTTSMD PVIGRVKEIR SIIEILAKKK KSNPMLVGPA
GVGKTAIVCG LAQLIAKDEA PGLTNYRIYN VDVGSMVANT GVRGEFEERV RKVVKEAEEC
PNIILFIDEI HTVISAGSTS GSLDFSNILK PSLAAGKIKI IGATTHDEYR KYMENDAAFC
RRFVKVTINE PSVEDSITML RGLRNKMELH HGIKIEDSAI VFSVKMAKKY IPSRRLPDIA
IDLVDTACAS ATIELESEPQ EIMNMKNKIW SLELERAAIE RDYKIKSGAD GKQGDAAHPE
KGYGKETKER LNEVEAKIDE ARRCLIPLEE AYEKERASVS EAKALKIKID QIYNKIEEAR
RNNDTYQVLD LQTEVLPVIE RKLKEIEGSI LITSAHIANV ISRWTDIPVK RLTLKENERL
LGMADRIKHR VFGQDAAVDR VVQCILRNRV GLSEPDRPIG AFLFLGPSGV GKTELAKAIA
FELFDDAKGM VVLDMSDYAN EISITKLLGV SAGYVGYAEG GALTEPVKEK PYNVVLFDEL
DLAHPKVVNV LYQLLDEGRV TDGKRNVIDF TNTVIVMTSN LGYEKILTGV YDPSEIEKAL
NDRFGPALIN RIDGICYFNG LSMVDLRNIL DYKLEMLNKE LNEKKIYLYL SDAVKQDVIN
RNYKPVYGAR PLKRALRSTF MDAIAHIILT DSKRIERAEK VLINSFTQEE GLEGTIIGDY
AYVVQYE
//
