ID   L7JU97_TRAHO            Unreviewed;       134 AA.
AC   L7JU97;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Zinc-binding protein of the histidine triad (HIT) family {ECO:0000313|EMBL:ELQ75053.1};
DE            EC=3.6.1.17 {ECO:0000313|EMBL:ELQ75053.1};
DE            EC=3.6.1.29 {ECO:0000313|EMBL:ELQ75053.1};
GN   ORFNames=THOM_2033 {ECO:0000313|EMBL:ELQ75053.1};
OS   Trachipleistophora hominis (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC   Trachipleistophora.
OX   NCBI_TaxID=72359 {ECO:0000313|EMBL:ELQ75053.1, ECO:0000313|Proteomes:UP000011185};
RN   [1] {ECO:0000313|EMBL:ELQ75053.1, ECO:0000313|Proteomes:UP000011185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA   Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA   Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA   Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA   Embley T.M.;
RT   "The genome of the obligate intracellular parasite Trachipleistophora
RT   hominis: new insights into microsporidian genome dynamics and reductive
RT   evolution.";
RL   PLoS Pathog. 8:E1002979-E1002979(2012).
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DR   EMBL; JH993997; ELQ75053.1; -; Genomic_DNA.
DR   AlphaFoldDB; L7JU97; -.
DR   STRING; 72359.L7JU97; -.
DR   VEuPathDB; MicrosporidiaDB:THOM_2033; -.
DR   HOGENOM; CLU_056776_3_0_1; -.
DR   InParanoid; L7JU97; -.
DR   OMA; QHVDHVH; -.
DR   Proteomes; UP000011185; Unassembled WGS sequence.
DR   GO; GO:0047710; F:bis(5'-adenosyl)-triphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004081; F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR46648:SF1; ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1; 1.
DR   PANTHER; PTHR46648; HIT FAMILY PROTEIN 1; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ELQ75053.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011185}.
FT   DOMAIN          6..105
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           90..94
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT                   ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        92
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ   SEQUENCE   134 AA;  15738 MW;  8B9025B752312868 CRC64;
     MDDKCVFCKI YTQNMNVLYK DARVFVILDI RPLSQGHLLV IPIKHGEFLY ENDEEDVSHA
     MRTIWKIVRV LGIKKFNILQ NNGHIQSVPH VHFHIVPYVD QVNCLKVDWK VVDVPSDYVQ
     KNVARLKEEL KELN
//