ID L7JUJ9_TRAHO Unreviewed; 593 AA.
AC L7JUJ9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=ATP-binding Cassette (ABC) Superfamily {ECO:0000313|EMBL:ELQ74691.1};
DE EC=3.6.3.44 {ECO:0000313|EMBL:ELQ74691.1};
GN ORFNames=THOM_2378 {ECO:0000313|EMBL:ELQ74691.1};
OS Trachipleistophora hominis (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Trachipleistophora.
OX NCBI_TaxID=72359 {ECO:0000313|EMBL:ELQ74691.1, ECO:0000313|Proteomes:UP000011185};
RN [1] {ECO:0000313|EMBL:ELQ74691.1, ECO:0000313|Proteomes:UP000011185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23133373; DOI=10.1371/journal.ppat.1002979;
RA Heinz E., Williams T.A., Nakjang S., Noel C.J., Swan D.C., Goldberg A.V.,
RA Harris S.R., Weinmaier T., Markert S., Becher D., Bernhardt J., Dagan T.,
RA Hacker C., Lucocq J.M., Schweder T., Rattei T., Hall N., Hirt R.P.,
RA Embley T.M.;
RT "The genome of the obligate intracellular parasite Trachipleistophora
RT hominis: new insights into microsporidian genome dynamics and reductive
RT evolution.";
RL PLoS Pathog. 8:E1002979-E1002979(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Heavy Metal importer (TC 3.A.1.210) subfamily.
CC {ECO:0000256|ARBA:ARBA00024363}.
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DR EMBL; JH994030; ELQ74691.1; -; Genomic_DNA.
DR AlphaFoldDB; L7JUJ9; -.
DR STRING; 72359.L7JUJ9; -.
DR VEuPathDB; MicrosporidiaDB:THOM_2378; -.
DR HOGENOM; CLU_000604_84_1_1; -.
DR InParanoid; L7JUJ9; -.
DR OMA; NFWRQVF; -.
DR Proteomes; UP000011185; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF402; IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:ELQ74691.1};
KW Hydrolase {ECO:0000313|EMBL:ELQ74691.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011185};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..304
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 341..581
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 573..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 68317 MW; 1926D55AB0E524D7 CRC64;
MASITTYEIL QIIMTKYVKD IPLIRMTIMP TLFLMFVARI MEVKVSEIVQ NASLEFSGYR
EGGTFKKYMI VGILSSLLIE LQGFIFKSSV QRAYRTALKS SLREYLLLNW SEFKMKGMGE
ITASIERRSS AVSEILDVFI INLLPVFFVL FLAVLKIYAI MGFTSSLIIL ISLITYTTVT
IKMAVWRNEI RKKLNLSINE SNNKLIDILS NYESILAFNN QNLELYKYDN KLATSEKHYV
KLWRTFYLLN FLQRFVLCVQ TGMIIYVGMC NKITSDQFVL YLSISKILAS NLDKLGYMYS
RFTAAILNAK MSFLDTVLPK KLYPIRYFDK KIVFRNVALP LSSENILNTS NDVFTYAISD
NYIFKNMSFE IKKGEKIALI GPNGIGKSNF LKMLLKFNEY TGSIKIDDDE LCTIDNYSLR
DLISYVPQNS YLVSGTVKEN IKYGNLVATD EEMIELCRSL NFHESFVRLS SGYETCIGEN
NSVLSGGEKQ KVAIARAMLK NAEIYLFDEP TANLDKKSEE TFFKRLAEDT QNKTVIVILH
NLELLDYFDR IMFLQKDRIQ EIKREEALKL MNSTKNEKST KNAQEMCDTS EEQ
//
