ID   L7LBU7_9ACTN            Unreviewed;       493 AA.
AC   L7LBU7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Putative hypoxanthine/guanine permease {ECO:0000313|EMBL:GAC57537.1};
GN   ORFNames=GOHSU_21_00290 {ECO:0000313|EMBL:GAC57537.1};
OS   Gordonia hirsuta DSM 44140 = NBRC 16056.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1121927 {ECO:0000313|EMBL:GAC57537.1, ECO:0000313|Proteomes:UP000053405};
RN   [1] {ECO:0000313|EMBL:GAC57537.1, ECO:0000313|Proteomes:UP000053405}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16056 {ECO:0000313|EMBL:GAC57537.1,
RC   ECO:0000313|Proteomes:UP000053405};
RA   Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia hirsuta NBRC 16056.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAC57537.1}.
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DR   EMBL; BANT01000021; GAC57537.1; -; Genomic_DNA.
DR   RefSeq; WP_005939832.1; NZ_BANT01000021.1.
DR   AlphaFoldDB; L7LBU7; -.
DR   STRING; 1121927.GOHSU_21_00290; -.
DR   eggNOG; COG2252; Bacteria.
DR   OrthoDB; 9808458at2; -.
DR   Proteomes; UP000053405; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053405};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        470..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   493 AA;  50760 MW;  F918BB307B3D8F3E CRC64;
     MSDTNEPVTV TEERPGVRPD TGAVARFFKI GQRGSTYGRE VRGGLVTFFT MAYIVVLNPI
     IIGGMAGVDR NLDVTGGFLP AGQVAAVTAL VAGVMTMLMG LIANFPFAIA AGLGINSLLA
     VTIAPTMSWP AAMGLVVIDG IIIVVLGLTG LRTAVFNAVP PELKSAIAAG IGAFIAFIGL
     VDSGFVSRTP GGPPVQLGVD GSIATVPTLI FVIGVLLMAV LTVRRIPGAL LIGIVIMTVV
     SLIVEAVWGL GSAQDRSGGW AMNVPGKPDS LFSLPDLSLV GQVDLIGALE HVGVLVAGIF
     VFTLVLSNFF DAMGTMTGVG KEGGLTDAKG NLPGIGKGLV VEGAGAIVGG GASASSNTVF
     VESAAGVAEG ARTGLANVVT GLLFLIAMFF TPLYEIVPME AVTPALVVVG ALMMAQVRDI
     DFARFDYALP AFLTIVIMPF TYSIANGIGV GFITWVVLAA ARGRWRSVHP LLWMVAALFV
     IYFARGPISD LIT
//