ID L7LIY9_9ACTN Unreviewed; 390 AA.
AC L7LIY9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN Name=prpC {ECO:0000313|EMBL:GAC61090.1};
GN ORFNames=GSI01S_14_01080 {ECO:0000313|EMBL:GAC61090.1};
OS Gordonia sihwensis NBRC 108236.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1223544 {ECO:0000313|EMBL:GAC61090.1, ECO:0000313|Proteomes:UP000035083};
RN [1] {ECO:0000313|EMBL:GAC61090.1, ECO:0000313|Proteomes:UP000035083}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 108236 {ECO:0000313|EMBL:GAC61090.1,
RC ECO:0000313|Proteomes:UP000035083};
RA Yoshida I., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia sihwensis NBRC 108236.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC61090.1}.
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DR EMBL; BANU01000014; GAC61090.1; -; Genomic_DNA.
DR RefSeq; WP_006896492.1; NZ_BANU01000014.1.
DR AlphaFoldDB; L7LIY9; -.
DR eggNOG; COG0372; Bacteria.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000035083; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000035083};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 280
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 331
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 390 AA; 43002 MW; 5FE9B4B3BED8DF58 CRC64;
MTDTPTAQSA AARTSGTDAI YTDAIYKGLA GVVVDTTAIS KVVPETNSLT YRGYPVQELA
EKCSMEQVAY LLWYGELPGD HQLQQFTQRE RAARRLDRSA QAVLARTPET CHPMDVVRTM
ISYLGTEDPD EDVAAPASLL DKAQRMFAVL PTIVAADLRR RRGLDPIAPH HGLGYAENFL
NMCFGEVPDP VVVRAFEKSM VLYAEHSFNA STFAARVVTS TGSDIYSAVT AAIGALKGPL
HGGANEAVMH DMIEIDRPER ARAWLDAKLS AGEKVMGFGH RVYKRGDSRV PTMYRALREV
SEHLGQSRWL AIYAELEEEM VSRTGIRPNL DFPTGPAYFL MGFDIPMFTP LFVMSRITGW
TAHIIEQTES NALIRPLSAY SGPQQRSVPA
//
