ID L7LPL3_9ACTN Unreviewed; 821 AA.
AC L7LPL3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Penicillin-binding protein 1 {ECO:0000313|EMBL:GAC61973.1};
GN Name=pon1 {ECO:0000313|EMBL:GAC61973.1};
GN ORFNames=GSI01S_27_00220 {ECO:0000313|EMBL:GAC61973.1};
OS Gordonia sihwensis NBRC 108236.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1223544 {ECO:0000313|EMBL:GAC61973.1, ECO:0000313|Proteomes:UP000035083};
RN [1] {ECO:0000313|EMBL:GAC61973.1, ECO:0000313|Proteomes:UP000035083}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 108236 {ECO:0000313|EMBL:GAC61973.1,
RC ECO:0000313|Proteomes:UP000035083};
RA Yoshida I., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia sihwensis NBRC 108236.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC61973.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BANU01000027; GAC61973.1; -; Genomic_DNA.
DR AlphaFoldDB; L7LPL3; -.
DR eggNOG; COG0744; Bacteria.
DR eggNOG; COG2815; Bacteria.
DR Proteomes; UP000035083; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06577; PASTA_pknB; 1.
DR Gene3D; 3.30.10.20; -; 1.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS51178; PASTA; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000035083}.
FT DOMAIN 724..787
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 788..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 86195 MW; F6A5345F6732EE02 CRC64;
MRKTSNLAGL AVAVVMAAVL VAGLLFPVAT GMGVLSNRAA ATMENSSSEL LGGTVPEVTT
VTDANGTPIA LLYDQYRYQV GYNDISQDMI RAIISIEDRR FLEHDGVDWK GTIRAALKNS
SSGEVQQGAS TLDQQYIKNY QLLVLARTEA EREAATETTP ARKLREVRMA LTLEQTLTDQ
AKREKGLDDA AAKQDAKKQI VTRYLNVVPF GNNAYGVEAA AQTYFGHSAK ELTVEQAAML
AGMVQSSSGL NPYTDPQATM ARRNTVLDTM IENFPERRAE LEAAKKKPLG VLPAPKTPVQ
GCISAHNNGF FCDYVLQYLA DNGIPRAQVM RGGYLIRTTL NPEVQADAVR SAQQHTAPDT
DGIATVMSIV APGKDSHDVL AMASSRNYGL DAKRDETVQP QPFSLVGDGA GSIFKLFTTA
AAMEKGLGTG SVLPIPSSVA VYGMGDSNGA FGCPVNAYCV KNAGAYPPSA SVTQALATSP
NTTFVQLLQQ VGVKPAVDMA VRLGLRSYNE PGTSGVGDQS LAEYVKKGNF GSFTLGPFAV
NALELSNVAA TLASGGTWCP PNPIASIQQV KRDQYGNAVL DQNGQRAMVN VPFNPPKCEQ
VVESGLANTL ANAMSEDDKG GGTSAAAASA AGWNLPLSGK TGTTEAHRSA AFLGFTNRLA
AAVYTYNDGS HPAGICTSPL RQCGDGNLYG GFEPARTWFS AIGPIATKFG PVALPPVDPQ
YVAGSDRGRI PQVSGLPASQ ATSRLQEAGF KVTELEVDST RPKGTVVFTA PSDSAMPGST
IAMYVSNGRG KTSGDGTSDK PAEKTVQVPG VGPVVIEVPG G
//
