ID L7MZN5_ANOCA Unreviewed; 620 AA.
AC L7MZN5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000005640.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005640.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005640.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005640.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005640.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Neurotoxin that produces dose-dependent hypolocomotion and
CC hyperalgesia in mice. May directly act on the central nervous system,
CC as it is 6500-fold more potent when administered
CC intracerebroventricularly than intraperitoneal.
CC {ECO:0000256|ARBA:ARBA00034460}.
CC -!- SIMILARITY: Belongs to the ohanin/vespryn family.
CC {ECO:0000256|ARBA:ARBA00009651}.
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DR AlphaFoldDB; L7MZN5; -.
DR Ensembl; ENSACAT00000005763.4; ENSACAP00000005640.4; ENSACAG00000010437.4.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT01030000234669; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; L7MZN5; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000010437; Expressed in adrenal gland and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd19762; Bbox2_TRIM7-like; 1.
DR CDD; cd16594; RING-HC_TRIM7-like_C-IV; 2.
DR CDD; cd12888; SPRY_PRY_TRIM7_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103:SF691; B30.2_SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 2.
DR Pfam; PF15227; zf-C3HC4_4; 2.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Toxin {ECO:0000256|ARBA:ARBA00022699};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 20..62
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 96..137
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 163..205
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 238..279
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 430..620
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 279..386
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 620 AA; 71039 MW; D70164A23C12D553 CRC64;
MAADSAARDP VKDLCEEATC SICLEYFKDP VSLECRHNFC RDCVTQCWEK SGTTETFCPQ
CKERVLQSNL RPNPSLANIV KIAKELSLQG PRRAEGRERV CEKHQEPLNV FCEDDGTFIC
VVCDRSKELR DNRKIPLGPA ARDYKVDLAS SAAKDPTGYE ITCSVCLEYF KDPVTLECGH
NFCQSCVTQY WEKSDTQETS CPQCREKVQQ RNLKSNWYLA NIIEITKKRP QGQKRAEDQE
RVCGKHQEPL KLFCKDDGTP ICCVCDRSKE HKDHTVIPVE EAAQEYKELM SVRQDILEKE
KEKNLIYKAE TNKEAQALLK QIEEKMEKTL EESTQVRQFL EEQEKHIQVQ MEELKKQITR
KRDEHLVLLS RKVSSLESLI QKMKEKCQHP PVELLQDVGS ILQRSEEKKI FEKRVAFLPK
LKWKVWEFCD LNSGLSAVMK QFRGKECVSN VSLDPDTACS YLVVSEDHQR VRWEAKNQDV
PDNPERFNPR AYVLGHEGFT KGRHFWEVVV ETEGGWSVGV AKKSVRRKGR VTVSPKEGIW
ALGNWAGSYR AIIHPSNSAL SLTGKIKRVR VCLNCDVNQL AFYNADTGDQ IYKLSNVPFI
GETVVPFFNV GRGGQLKVSL
//
