ID L7N148_MYOLU Unreviewed; 732 AA.
AC L7N148;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002967.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002967.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002967.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AAPE02033114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; L7N148; -.
DR STRING; 59463.ENSMLUP00000002967; -.
DR Ensembl; ENSMLUT00000003264.2; ENSMLUP00000002967.2; ENSMLUG00000003263.2.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159592; -.
DR HOGENOM; CLU_009051_6_0_1; -.
DR InParanoid; L7N148; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR045791; Sema4F_C.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF72; SEMAPHORIN-4F; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF19428; Sema4F_C; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..473
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 660..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 79776 MW; 7C4DFCF8BE1FA251 CRC64;
IPLFPLFLPE ADIYLNRFSI PQTYNYSVLL VDPASHTLFV GARDTIFALS LPFSGERPRR
INWMVPEGEK QNCMAKGKEE DECHNFVQIL AIVNDSHLLT CGTFAFDPKC GVIAVSSFQQ
VEGIESGRAK CPFGPAQRSA AIMAGGALYA ATVRNFLGTE PIISRAVRRA EGQAEDWIRT
EAYWLDASAF VAAMALRPAE WGDEDGDKEI YFFFTETSQA FDSKEHLKVP RVARVCAGDL
GGQRMLQKRW TTFLKADLRC PGPEDGRTSS VLRDMAILRP ETGVGAPIFY GIFFFQWKGA
AISAVCAFRP QDIRTVLNGP FRELKDVCNR GQSVMESEVP QPRPGECIAN NPKFQQFNSS
LSLPDRVLTF IRDHPLMYRP VLPADGHSLL VTTDTVYLRV VAHRVASLSG KEYDVLYLGT
EDGHLQRAVR IGSELSVLED LALFPEPQPV ENMKLYQSWL LVGSHTEVTQ VNTTNCGRLQ
SCSECILAQD PVCAWSFQLD ACVAHAGEHG GLVQDIESAD VSSLCPKEPG EHPVVFEVLV
ATAVHVVLPC SPSSAWASCV WHQPSGVTAF TPRRDGLEVV VTPGAMGAYA CECQEGGAAR
VVAAYSLVWG SQLGPARRAR TVGTGLAVFF LGILAASLTL FLIGLCQQRQ RQRELLARDK
VGLDPGAPPS GTPSLNQDPP SSPEDDQLPL ALGKRGSGFG GFPPPFLLDP CPSPAHNRLT
EAPLATCDET SI
//
