ID L7N188_MYOLU Unreviewed; 755 AA.
AC L7N188;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=EvC ciliary complex subunit 2 {ECO:0008006|Google:ProtNLM};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004881.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004881.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004881.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AAPE02060885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; L7N188; -.
DR STRING; 59463.ENSMLUP00000004881; -.
DR Ensembl; ENSMLUT00000005350.2; ENSMLUP00000004881.2; ENSMLUG00000004949.2.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR InParanoid; L7N188; -.
DR OMA; XENVEEL; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 608..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 457..484
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 521..555
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 755 AA; 86315 MW; A32CE8E6E5BB4131 CRC64;
DFLFEQEEVE ELMDFFQASK RYHLSKRFGH REYLVQNMQS AETRVQGLLS AAAAQLTLLI
QKHERAGYLD EEQTEELMER AQTEVFSIKQ KLDNDLKQEK KKLHQKLIVK RRREMLQKHK
EQRREQLSVG EAFRAAEDVG QYLGQWRSLV AAQGAALEEL QERLDQAALD ELRALTLSLF
EKATEELRRL QSSALTQELL KRGVPWLFLQ QILEEHAREL AARAEQLEAE ERGRDQEGVR
SVRQRLKDDA LEASAEEQAE LRHWGRWVFL RLCGSPFSLS EEELLRMRQD VHSCFAQMDR
SLALPRIRAR VLLQRLHTAW REAEFLKLDQ ALAAPELQPQ AKARKPRAKS KSKTDLLRKC
IEDKIQLFDG PAPEDLLEKV RAELLRERVQ QLEAQEGRFA ESLVALQFQK AAGAARTLWA
YTALLSVQHL LLEELSESET LTKAACAQIL ESHSPMPREA QEELQELERK LEEELAHQEA
AQRQRALAGR QQWAEDGPGL LTEPEDADSE GQVSAALRRA LGRSQELLER QQQSLREEQE
RSVVLEDLLE RMEADAFVGL YSQELRLASY LSKLTMVPAG TLRRLLSVAL PAAPQPELLA
LLESLSQKQP DPAAEHDGGG EQADLGRRGK RRKKHQGWWQ ALESRLRGEL RSSGLDKMLW
ARRRKESILR KTCPPLRERT VCSGKGGWPH LSLESSGDLV PVPIVGAEAI DLLNMGEKLF
IFRNPAEPEI SLRVPPRKKK NFLNAKKAAW AAGMD
//
