GenomeNet

Database: UniProt
Entry: L7N1Y0_MOUSE
LinkDB: L7N1Y0_MOUSE
Original site: L7N1Y0_MOUSE 
ID   L7N1Y0_MOUSE            Unreviewed;      4068 AA.
AC   L7N1Y0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   SubName: Full=Dynein, axonemal, heavy chain 7B {ECO:0000313|Ensembl:ENSMUSP00000068738.8};
GN   Name=Dnah7b {ECO:0000313|Ensembl:ENSMUSP00000068738.8,
GN   ECO:0000313|MGI:MGI:2684953};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000068738.8, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000068738.8, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068738.8,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000068738.8}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068738.8};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   RefSeq; NP_001153858.1; NM_001160386.1.
DR   SMR; L7N1Y0; -.
DR   STRING; 10090.ENSMUSP00000068738; -.
DR   iPTMnet; L7N1Y0; -.
DR   PhosphoSitePlus; L7N1Y0; -.
DR   EPD; L7N1Y0; -.
DR   MaxQB; L7N1Y0; -.
DR   PaxDb; 10090-ENSMUSP00000068738; -.
DR   ProteomicsDB; 365814; -.
DR   Ensembl; ENSMUST00000069293.10; ENSMUSP00000068738.8; ENSMUSG00000041144.13.
DR   UCSC; uc007awx.2; mouse.
DR   AGR; MGI:2684953; -.
DR   MGI; MGI:2684953; Dnah7b.
DR   VEuPathDB; HostDB:ENSMUSG00000041144; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   GeneTree; ENSGT00940000155282; -.
DR   HOGENOM; CLU_000038_0_0_1; -.
DR   InParanoid; L7N1Y0; -.
DR   OMA; GRDIPCS; -.
DR   PhylomeDB; L7N1Y0; -.
DR   BioGRID-ORCS; 227058; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Dnah7b; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; L7N1Y0; Protein.
DR   Bgee; ENSMUSG00000041144; Expressed in spermatocyte and 59 other cell types or tissues.
DR   ExpressionAtlas; L7N1Y0; baseline and differential.
DR   GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0036156; C:inner dynein arm; ISO:MGI.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0003341; P:cilium movement; ISO:MGI.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46961:SF9; DHC_N2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Proteomics identification {ECO:0007829|EPD:L7N1Y0,
KW   ECO:0007829|ProteomicsDB:L7N1Y0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          2284..2319
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2875..2923
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        150..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4068 AA;  466690 MW;  0849F6AA471F8D0F CRC64;
     MPQRATLLDL SESSAPNLAD ADDRKWIPPQ RSRPILPGPQ VLAAMSSKKD KLSTKGTSKP
     PARFLPQLPM DKLSSREKDK LPTTVLPQLT STGVKPQWQQ IAPSFHLNMK QENPILEPYP
     VKNEQSFADY MEYFQQKGKQ LYQIDDKRSG PSTSRSKVKS PQKERENFRS TLVKLIMQQD
     GDLESDVIDE SGIPKATTTA REKDISRYYY YIRHGLDTDH VAPMEDSWLE HVLQLVPQHL
     KILNNSIMVL SDEIREDYLL SVKKSIVDFV LKDPRKKDDD GKITELPPHR AEMEVLPKPW
     RRSFLSACSY IRDHLNAMNP MMLAVLDLWH STFKKLRLVD IEEFHNRQDS LELSEFQNIV
     IKHMESAKEM LLKTWFPEVQ NIYYKGNKKK QLPTGKSSAK LDSFFNCAAT LMTLQLQDLI
     LVSMQDFTDL IAQPPESTRA FEHPGFIMRL ILDKKTIKFA PDFNDYIDIL INVYEIMIKM
     VSFVPRVETK LYSQWESKSK PTTLKPIILN EIIDTHKEKI REVVLRESVA PTEHLKMYDK
     YQFLITGKAE RDIDEFLFQS QNYERLIEEI RKYQKLEEEI QYTSRKAVRL GMFEMHCEEL
     IKSLVKRADV ICGKLIAKMF RDHQEVNTML CDEFEKIAEK ALSMPLNTAE LMEMKAHVQK
     LETTDMLELR QRLVDSKNCL AFLIECVNFS PADIRLNNSV FQWYGRMGEI FDEHRKIIKD
     KTEQYQEALK FRCERFVEEL ESYAKQVEEF HTFGDLLDVQ RYLKKAQVLN GKLDAAADKI
     EQFNAEEEAY GWVPSVYPQR KKIQDGLNPY LRLYETAVEF STKHRGWTEG PYHKVNPDQV
     EADVGNYWRG LYKLEKVFHD SPNALAMTKK VQSMVEEFKQ YIPLIQVICN PGLRPRHWEA
     MSTIVGFPLL PSDDSTVFSF IDMNLEPFLD RFEGISEAAS KEYSLEKAMD KMMTEWDSME
     FVILPYRESG TYILSSVDDI QMLLDDHIIK TQTMRGSPFI KPYEKQMREW EGKLLLLQEI
     LDEWLKVQAT WLYLEPIFSS PDIMSQMPEE GRRFKAVDKT WRDVMKTVVQ DKRVLAVVTI
     ERMLERLKKS NELLELILKG LNEYLEKKRL FFPRFFFLSN DELLEILSET KDPTRVQPHL
     KKCFEGIAKV EFTETLDITH MKSSEGEVVE LVDTISTAKA RGQVEKWLVE LERTMIKSIH
     KVIGDAIAAY TKNSRISWVR DWPGQTVLCV SQTFWTVEVQ TAIPKGHRAL EGYLAKCNHQ
     IDDIVTLVRG KLSKQNRVTL GALVVLDVHA RDVLASLVDK KISDDSDFQW LSQLRYYWQE
     NNLETKMINA GLRYGYEYLG NSPRLVITPL TDRCYRTLFG ALHLHLGGAP EGPAGTGKTE
     TTKDLAKAVA KQCVVFNCSD GLDYLALGKF FKGLLSCGAW ACFDEFNRID LEVLSVVAQQ
     ILTIQRGINA GTELLVFEGT ELKLDPTCAV FITMNPGYAG RSELPDNLKA LFRTVAMMVP
     DYAMIAEIVL YSCGFVTARP LSIKIVATYR LCSEQLSSQH HYNYGMRAVK SVLTAAGNLK
     LKYPNENEEI LLLRSIIDVN LPKFLSHDLP LFEGITSDLF PGVKLPKPDY NELLAAIREN
     CHTMNLQMTD FFSEKILQIY EMMIVRHGFM IVGEPFGGKT SAYRVLAGAL NDICEKGLME
     ENKVQITVLN PKSVTMGQLY GQFDLVSHEW SDGILAVSFR AFAASSTPDR KWLIFDGPVD
     AVWIENMNTV LDDNKKLCLM SGEIIQMSPQ MNLIFEPMDL EVASPATVSR CGMIYMEPHM
     LGWRPLMVSW INTLPQSVSI IQKEFIEGLF DRMVPLSVEF IRRHTKELSP TSDTNLVQSL
     MNLIDCFMDD FADENKQKER NDRESFSLLE GIFMFSLAWS VGATCTDDDR LKFDKILREL
     MEGPISDLTR NKFKLLSGTE QTSSKVFIVP FPEKGTIYEY QFIPEGLGRW DKWIKKLADT
     PPIPKDVQFI EIIVPTLDTI RYSALMHLLT THQKPSIFVG PTGTGKSVYI INFLLNQLNK
     DIYKPLIVNF SAQTTAAQTQ NIIMSKLDKR RKGVFGPPLG KRMIVFVDDV NMPAREVYGA
     QPPIELLRQW LDHWNWYDLK DCSVIKLVDI QIMCAMGPPG GGRNPITPRY MRHFNIVTIN
     EFSDKSMFTI FSRILAWHLR TCYKFPDDFL DLTTQIVNGT MALYKDAMKN LLPTPAKSHY
     LFNLRDFSRV IQGVCLSRPE TAENKEAIKR LWVHEVLRVY YDRLVDNADR SWLIHYIQEI
     LKNYMQEDFH DLFKNLDFNQ DGTVEEDDLR SLMFCDFHDP KREDFGYREI ANVDALRMIV
     EGHLDEYNNM SKKPMNLVLF RFAIEHISRI SRILKQPRSH ALLVGVGGSG RQSVTRLAAH
     MADYSLFQVE ISKGYGSHEW HEDLKVILRK CAENDMQGVF LFTDTQIKRE SFLEDVNNLL
     NAGEVPNLFA LDEKQEICEK MRQLDRQRDK TRQTDGSPIA LFNMFIDRCR NQLHVVLAMS
     PIGDAFRIRL RKFPALVNCC TIDWFQSWPE DALEAVASRF LEDIEMSEEI QEGCIDMCKR
     FHTSTINLST SFHNELQRYN YVTPTSYLEL ISTFKLLLEK KRNEVMKMKR RYEVGLDKLD
     SASSQVATMQ SELEALHPQL KVASREVDEM MIIIERESME VAKTEKIVKA DETVANDQAM
     AAKAIKDECD ADLAEALPIL ESALAALDTL TAQDITVVKS MKSPPAGVKL VMEAICILKG
     IKADKIPDPT GSGKKIEDFW GPAKRLLGDI RFLQSLHEYD KDNIPPAYMN IIRKSYIPNP
     DFVPEKIRNA STAAEGLCKW VIAMDSYDKV AKIVAPKKIK LAAAEGKLRI AMEGLRKKQA
     ALYEVQDKLA KLQDTLELNK QKKADLENQV DLCSKKLERA EQLIGGLGGE KTRWSNSALE
     LGHLYINLTG DILISSGVVA YLGAFTSNYR QNQTQEWSQS CKERDIPCSD DYSLMGTLGE
     AVTIRAWNIA GLPSDSFSID NGIIIMNARR WPLMIDPQGQ ANKWIKNMEK TNSLQLIKLS
     DPDYVRTLEN CIQFGTPVLL ENVGEELDPI LEPLLLKQTF KQGGSTCIRL GDSTIEYAPD
     FRFYITTKLR NPHYLPETSV KVTLLNFMIT PEGMQDQLLG IVVARERPDL EEEKQSLIVQ
     GADNKRQLKE IEDKILEVLS LSEGNILEDE TAIKILSSSK SLANEISQKQ EVAEETEKKI
     DNTRMGYRII AIHSSILFFS IADLANIEPM YQYSLTWFIN LFILSIENSE KSDILSKRLQ
     ILRDHFTYSL YVNICRSLFE KDKLLFSFCL TVNLLIHENA INKTEWRFLL TGGIGLDNPY
     TNPCTWLPQK SWDEICRLDD LPAFKTIRRE FMRLKDGWKK VYDSMEPHHE MFPEDWENKA
     NDFQRMLIIR CLRPDKVIPM LQEFIIKKLG RPFIEPPPFD LAKAFGDSNC CAPLIFVLSP
     GADPMNALLK FADDQGYGGS KLSSLSLGQG QGPIAMKMLE KAVKDGTWVV LQNCHLATSW
     MPTLEKVCEE LSAESTHPDF RIWLTSYPSP NFPVSVLQNG VKMTNEAPKG LRANIIRSYL
     MDPISDPEFF GSCKKPEEFK KLLYGLCFFH ALVQERRKFG PLGWNIPYEF NETDLRISVQ
     QLHMFLDQYE ELPYDALRYM TGECNYGGRV TDDWDRRTLR SILNKFFCTE LVENPQYKFD
     SSGIYFVPPS GDHKSYINYT KTLPLIPAPE VFGMNANADI TKDQSETQLL FDNILLTQSQ
     SSGSGTKSSD EVVNEVAGDI LSKLPNNFDV EAAMRRYPTT YTQSMNTVLV QEMGRFNKLL
     ITIRESCINI QKAIKGLVVM STELEEVVSS ILNVKIPVMW MGKSYPSLKP LGSYVNDFLE
     RLKFLQQWYE VGPPPVFWLS GFFFTQAFLT GAQQNFARKF TIPIDLLGFD YEVMDDKEYK
     NAPEDGVYIH GLFLDGASWN RKTKKLAESH PKVLYDTVPV MWLKPCKKSD IPKRPSYVAP
     LYKTSERRGT LSTTGHSTNF VIAMILPSDQ PKEHWIGRGV ALLCQLNS
//
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