ID L7N1Y0_MOUSE Unreviewed; 4068 AA.
AC L7N1Y0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Dynein, axonemal, heavy chain 7B {ECO:0000313|Ensembl:ENSMUSP00000068738.8};
GN Name=Dnah7b {ECO:0000313|Ensembl:ENSMUSP00000068738.8,
GN ECO:0000313|MGI:MGI:2684953};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000068738.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000068738.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068738.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000068738.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068738.8};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; NP_001153858.1; NM_001160386.1.
DR SMR; L7N1Y0; -.
DR STRING; 10090.ENSMUSP00000068738; -.
DR iPTMnet; L7N1Y0; -.
DR PhosphoSitePlus; L7N1Y0; -.
DR EPD; L7N1Y0; -.
DR MaxQB; L7N1Y0; -.
DR PaxDb; 10090-ENSMUSP00000068738; -.
DR ProteomicsDB; 365814; -.
DR Ensembl; ENSMUST00000069293.10; ENSMUSP00000068738.8; ENSMUSG00000041144.13.
DR UCSC; uc007awx.2; mouse.
DR AGR; MGI:2684953; -.
DR MGI; MGI:2684953; Dnah7b.
DR VEuPathDB; HostDB:ENSMUSG00000041144; -.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000155282; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; L7N1Y0; -.
DR OMA; GRDIPCS; -.
DR PhylomeDB; L7N1Y0; -.
DR BioGRID-ORCS; 227058; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Dnah7b; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; L7N1Y0; Protein.
DR Bgee; ENSMUSG00000041144; Expressed in spermatocyte and 59 other cell types or tissues.
DR ExpressionAtlas; L7N1Y0; baseline and differential.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0036156; C:inner dynein arm; ISO:MGI.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0003341; P:cilium movement; ISO:MGI.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0036159; P:inner dynein arm assembly; ISO:MGI.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF9; DHC_N2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:L7N1Y0,
KW ECO:0007829|ProteomicsDB:L7N1Y0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 2284..2319
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2875..2923
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 150..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4068 AA; 466690 MW; 0849F6AA471F8D0F CRC64;
MPQRATLLDL SESSAPNLAD ADDRKWIPPQ RSRPILPGPQ VLAAMSSKKD KLSTKGTSKP
PARFLPQLPM DKLSSREKDK LPTTVLPQLT STGVKPQWQQ IAPSFHLNMK QENPILEPYP
VKNEQSFADY MEYFQQKGKQ LYQIDDKRSG PSTSRSKVKS PQKERENFRS TLVKLIMQQD
GDLESDVIDE SGIPKATTTA REKDISRYYY YIRHGLDTDH VAPMEDSWLE HVLQLVPQHL
KILNNSIMVL SDEIREDYLL SVKKSIVDFV LKDPRKKDDD GKITELPPHR AEMEVLPKPW
RRSFLSACSY IRDHLNAMNP MMLAVLDLWH STFKKLRLVD IEEFHNRQDS LELSEFQNIV
IKHMESAKEM LLKTWFPEVQ NIYYKGNKKK QLPTGKSSAK LDSFFNCAAT LMTLQLQDLI
LVSMQDFTDL IAQPPESTRA FEHPGFIMRL ILDKKTIKFA PDFNDYIDIL INVYEIMIKM
VSFVPRVETK LYSQWESKSK PTTLKPIILN EIIDTHKEKI REVVLRESVA PTEHLKMYDK
YQFLITGKAE RDIDEFLFQS QNYERLIEEI RKYQKLEEEI QYTSRKAVRL GMFEMHCEEL
IKSLVKRADV ICGKLIAKMF RDHQEVNTML CDEFEKIAEK ALSMPLNTAE LMEMKAHVQK
LETTDMLELR QRLVDSKNCL AFLIECVNFS PADIRLNNSV FQWYGRMGEI FDEHRKIIKD
KTEQYQEALK FRCERFVEEL ESYAKQVEEF HTFGDLLDVQ RYLKKAQVLN GKLDAAADKI
EQFNAEEEAY GWVPSVYPQR KKIQDGLNPY LRLYETAVEF STKHRGWTEG PYHKVNPDQV
EADVGNYWRG LYKLEKVFHD SPNALAMTKK VQSMVEEFKQ YIPLIQVICN PGLRPRHWEA
MSTIVGFPLL PSDDSTVFSF IDMNLEPFLD RFEGISEAAS KEYSLEKAMD KMMTEWDSME
FVILPYRESG TYILSSVDDI QMLLDDHIIK TQTMRGSPFI KPYEKQMREW EGKLLLLQEI
LDEWLKVQAT WLYLEPIFSS PDIMSQMPEE GRRFKAVDKT WRDVMKTVVQ DKRVLAVVTI
ERMLERLKKS NELLELILKG LNEYLEKKRL FFPRFFFLSN DELLEILSET KDPTRVQPHL
KKCFEGIAKV EFTETLDITH MKSSEGEVVE LVDTISTAKA RGQVEKWLVE LERTMIKSIH
KVIGDAIAAY TKNSRISWVR DWPGQTVLCV SQTFWTVEVQ TAIPKGHRAL EGYLAKCNHQ
IDDIVTLVRG KLSKQNRVTL GALVVLDVHA RDVLASLVDK KISDDSDFQW LSQLRYYWQE
NNLETKMINA GLRYGYEYLG NSPRLVITPL TDRCYRTLFG ALHLHLGGAP EGPAGTGKTE
TTKDLAKAVA KQCVVFNCSD GLDYLALGKF FKGLLSCGAW ACFDEFNRID LEVLSVVAQQ
ILTIQRGINA GTELLVFEGT ELKLDPTCAV FITMNPGYAG RSELPDNLKA LFRTVAMMVP
DYAMIAEIVL YSCGFVTARP LSIKIVATYR LCSEQLSSQH HYNYGMRAVK SVLTAAGNLK
LKYPNENEEI LLLRSIIDVN LPKFLSHDLP LFEGITSDLF PGVKLPKPDY NELLAAIREN
CHTMNLQMTD FFSEKILQIY EMMIVRHGFM IVGEPFGGKT SAYRVLAGAL NDICEKGLME
ENKVQITVLN PKSVTMGQLY GQFDLVSHEW SDGILAVSFR AFAASSTPDR KWLIFDGPVD
AVWIENMNTV LDDNKKLCLM SGEIIQMSPQ MNLIFEPMDL EVASPATVSR CGMIYMEPHM
LGWRPLMVSW INTLPQSVSI IQKEFIEGLF DRMVPLSVEF IRRHTKELSP TSDTNLVQSL
MNLIDCFMDD FADENKQKER NDRESFSLLE GIFMFSLAWS VGATCTDDDR LKFDKILREL
MEGPISDLTR NKFKLLSGTE QTSSKVFIVP FPEKGTIYEY QFIPEGLGRW DKWIKKLADT
PPIPKDVQFI EIIVPTLDTI RYSALMHLLT THQKPSIFVG PTGTGKSVYI INFLLNQLNK
DIYKPLIVNF SAQTTAAQTQ NIIMSKLDKR RKGVFGPPLG KRMIVFVDDV NMPAREVYGA
QPPIELLRQW LDHWNWYDLK DCSVIKLVDI QIMCAMGPPG GGRNPITPRY MRHFNIVTIN
EFSDKSMFTI FSRILAWHLR TCYKFPDDFL DLTTQIVNGT MALYKDAMKN LLPTPAKSHY
LFNLRDFSRV IQGVCLSRPE TAENKEAIKR LWVHEVLRVY YDRLVDNADR SWLIHYIQEI
LKNYMQEDFH DLFKNLDFNQ DGTVEEDDLR SLMFCDFHDP KREDFGYREI ANVDALRMIV
EGHLDEYNNM SKKPMNLVLF RFAIEHISRI SRILKQPRSH ALLVGVGGSG RQSVTRLAAH
MADYSLFQVE ISKGYGSHEW HEDLKVILRK CAENDMQGVF LFTDTQIKRE SFLEDVNNLL
NAGEVPNLFA LDEKQEICEK MRQLDRQRDK TRQTDGSPIA LFNMFIDRCR NQLHVVLAMS
PIGDAFRIRL RKFPALVNCC TIDWFQSWPE DALEAVASRF LEDIEMSEEI QEGCIDMCKR
FHTSTINLST SFHNELQRYN YVTPTSYLEL ISTFKLLLEK KRNEVMKMKR RYEVGLDKLD
SASSQVATMQ SELEALHPQL KVASREVDEM MIIIERESME VAKTEKIVKA DETVANDQAM
AAKAIKDECD ADLAEALPIL ESALAALDTL TAQDITVVKS MKSPPAGVKL VMEAICILKG
IKADKIPDPT GSGKKIEDFW GPAKRLLGDI RFLQSLHEYD KDNIPPAYMN IIRKSYIPNP
DFVPEKIRNA STAAEGLCKW VIAMDSYDKV AKIVAPKKIK LAAAEGKLRI AMEGLRKKQA
ALYEVQDKLA KLQDTLELNK QKKADLENQV DLCSKKLERA EQLIGGLGGE KTRWSNSALE
LGHLYINLTG DILISSGVVA YLGAFTSNYR QNQTQEWSQS CKERDIPCSD DYSLMGTLGE
AVTIRAWNIA GLPSDSFSID NGIIIMNARR WPLMIDPQGQ ANKWIKNMEK TNSLQLIKLS
DPDYVRTLEN CIQFGTPVLL ENVGEELDPI LEPLLLKQTF KQGGSTCIRL GDSTIEYAPD
FRFYITTKLR NPHYLPETSV KVTLLNFMIT PEGMQDQLLG IVVARERPDL EEEKQSLIVQ
GADNKRQLKE IEDKILEVLS LSEGNILEDE TAIKILSSSK SLANEISQKQ EVAEETEKKI
DNTRMGYRII AIHSSILFFS IADLANIEPM YQYSLTWFIN LFILSIENSE KSDILSKRLQ
ILRDHFTYSL YVNICRSLFE KDKLLFSFCL TVNLLIHENA INKTEWRFLL TGGIGLDNPY
TNPCTWLPQK SWDEICRLDD LPAFKTIRRE FMRLKDGWKK VYDSMEPHHE MFPEDWENKA
NDFQRMLIIR CLRPDKVIPM LQEFIIKKLG RPFIEPPPFD LAKAFGDSNC CAPLIFVLSP
GADPMNALLK FADDQGYGGS KLSSLSLGQG QGPIAMKMLE KAVKDGTWVV LQNCHLATSW
MPTLEKVCEE LSAESTHPDF RIWLTSYPSP NFPVSVLQNG VKMTNEAPKG LRANIIRSYL
MDPISDPEFF GSCKKPEEFK KLLYGLCFFH ALVQERRKFG PLGWNIPYEF NETDLRISVQ
QLHMFLDQYE ELPYDALRYM TGECNYGGRV TDDWDRRTLR SILNKFFCTE LVENPQYKFD
SSGIYFVPPS GDHKSYINYT KTLPLIPAPE VFGMNANADI TKDQSETQLL FDNILLTQSQ
SSGSGTKSSD EVVNEVAGDI LSKLPNNFDV EAAMRRYPTT YTQSMNTVLV QEMGRFNKLL
ITIRESCINI QKAIKGLVVM STELEEVVSS ILNVKIPVMW MGKSYPSLKP LGSYVNDFLE
RLKFLQQWYE VGPPPVFWLS GFFFTQAFLT GAQQNFARKF TIPIDLLGFD YEVMDDKEYK
NAPEDGVYIH GLFLDGASWN RKTKKLAESH PKVLYDTVPV MWLKPCKKSD IPKRPSYVAP
LYKTSERRGT LSTTGHSTNF VIAMILPSDQ PKEHWIGRGV ALLCQLNS
//