ID L7N1Z4_MOUSE Unreviewed; 861 AA.
AC L7N1Z4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Vomeronasal 2, receptor 31 {ECO:0000313|Ensembl:ENSMUSP00000074613.7};
GN Name=Vmn2r31 {ECO:0000313|Ensembl:ENSMUSP00000074613.7,
GN ECO:0000313|MGI:MGI:3757688};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000074613.7, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000074613.7, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074613.7,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000074613.7}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074613.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; NP_001098532.1; NM_001105062.1.
DR AlphaFoldDB; L7N1Z4; -.
DR SMR; L7N1Z4; -.
DR STRING; 10090.ENSMUSP00000074613; -.
DR PaxDb; 10090-ENSMUSP00000074613; -.
DR Ensembl; ENSMUST00000075108.9; ENSMUSP00000074613.7; ENSMUSG00000096373.4.
DR UCSC; uc012exs.1; mouse.
DR AGR; MGI:3757688; -.
DR MGI; MGI:3757688; Vmn2r31.
DR VEuPathDB; HostDB:ENSMUSG00000096373; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR InParanoid; L7N1Z4; -.
DR OMA; DQHPNQK; -.
DR OrthoDB; 4332316at2759; -.
DR PhylomeDB; L7N1Z4; -.
DR BioGRID-ORCS; 100042591; 5 hits in 38 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; L7N1Z4; Protein.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF436; EC2-V2R PHEROMONE RECEPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..861
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003982258"
FT TRANSMEM 586..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 586..850
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 861 AA; 98648 MW; 7E9CE1972E2FE403 CRC64;
MFTLMGVFFF LNIPLFMANF IDPRCFWRIN LNEIQDEYLG LTCAFILAAV QKPIEKDYFN
KTLNFLKTTK NHKYALALAF AMDEINRNPD LLPNMSLIIR YTLGRCDGKT VIPTPYLFHK
KKQSPIPNYF CNEETMCSFL LTGPNWGVSI SFWKYLDSFL SPRILQLTYG PFSSIFSDDE
QYPYLYQMAP KDTSLALAMV SFILYFNWNW IGLVIPDDDQ GNQFLLELKK QSENKEICFA
FVKMISVDDI SFEHKTEMYY KQIVMSSSNV IIIYEETINF IDLIFRMWEP PVLQRIWITT
KQWNFPTSKR DITHGTFYGS LTFLPHHGGI SGFKDFVQTW FHLRSKDLYL VMPEWKYFKY
ESSASKCKIL KNNSSDASFD WLMEQKFDMA FSESSHNIYN AVHAIAHALH EVNLQQVDNQ
AIDNGKGASS HCLKVNSFLR KIHFTNPLGD KVIMKQRVIM QEEYDIFHFG NLSQHLGIKV
KLGKFSPYFS HGRNFHLYVD MLEVATGSRK MPSSVCSAEC SPGFRRLWKE GMAACCFVCS
PCPENEISNE TNMDQCVNCP EYQYANTEQN KCIQKGVTFL SYEDPLGMAL ALMAFCFSAF
TAVVLCVFVK HHDTPIVKAN NRILSYLLLI SLMSCFLCSF FYIGHPNRAT CVLQQITFGI
VFTVAVSTVL AKTVTVVLAF KVTDPGRRLR NFLVSGTPNY IIPICSLLQC VLCAIWIEVS
PPFVDIDEHS QHGHIIIVCN KGSVTAFYCV LGYLACLALG SFTLAFLAKN LPDTFNEAKF
LTFSMLVFFS VWVTFLPVYH STKGKVMVAV EIFSILASSA GMLGCIFAPK IYIILMRPER
NSTQKIKVRN STQKIKEKSY F
//
