ID L7N2B5_MOUSE Unreviewed; 852 AA.
AC L7N2B5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Vomeronasal 2, receptor 45 {ECO:0000313|Ensembl:ENSMUSP00000129466.3};
GN Name=Vmn2r45 {ECO:0000313|Ensembl:ENSMUSP00000129466.3,
GN ECO:0000313|MGI:MGI:3757883};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129466.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000129466.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129466.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000129466.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129466.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; NP_001098545.1; NM_001105075.1.
DR AlphaFoldDB; L7N2B5; -.
DR SMR; L7N2B5; -.
DR STRING; 10090.ENSMUSP00000129466; -.
DR PaxDb; 10090-ENSMUSP00000129466; -.
DR ProteomicsDB; 310335; -.
DR Ensembl; ENSMUST00000164845.4; ENSMUSP00000129466.3; ENSMUSG00000090662.4.
DR GeneID; 100042810; -.
DR KEGG; mmu:100042810; -.
DR UCSC; uc012eyg.1; mouse.
DR AGR; MGI:3757883; -.
DR CTD; 100042810; -.
DR MGI; MGI:3757883; Vmn2r45.
DR VEuPathDB; HostDB:ENSMUSG00000090662; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR InParanoid; L7N2B5; -.
DR OMA; QHEICSA; -.
DR OrthoDB; 4332316at2759; -.
DR PhylomeDB; L7N2B5; -.
DR BioGRID-ORCS; 100042810; 3 hits in 39 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; L7N2B5; Protein.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF543; VOMERONASAL 2, RECEPTOR 29-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..852
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003982289"
FT TRANSMEM 586..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 586..850
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 852 AA; 97683 MW; 0FE8F0E652DADE87 CRC64;
MFIFMEVFFL LNITLLMANF IDPRCFWRIN LDEIMDEYLG LSCAFILAAV QTPIENDYFN
KTLNVLKTTK NHKYALALVF AMDEINRNPD LLPNMSLIIR YSLGHCDGKT VIPTPYLFRK
KKESPIPNYF CNEETMCSYL LTGPHWEVSL GFWKHVNSFL SPRILQLTYG PFHSIFSDDE
QYPYLYQMAP KDTSLALAMV SFILYFSWNW IGLVIPDDDQ GNQFLLELKK QSENKEICFA
FVKMISVDDV SFPQNIEMYY NQIVMSSTNV IIIYGETYNF IDLIFRMWEP PILQRIWITT
KQLNFPTRKT DISHGTFYGS LTFLPHHGVI SGFKNFVQTW FHLRNTDLYL VMQEWKYFNY
EDSASTCKIK KNNSSNASFD WLMEQKFDMT FSENSHNIYN AVHAIAHALH EMNLQQADNQ
AIDNGKGASS HCLKVNSFLR RIYFTNPPGD KVFMKQRVIM QDEYDIVHFV NLSQHLGIKM
KLGKFSPYLP HGRHSHLYVD MIELATGRRK MPSSVCSADC SPGFRRLWKE GMAACCFVCS
PCPENEISNE TNMDQCMNCP EYQYANTEQN KCIQKGVTFL SYEDPLGMAL ALMAFCFSAF
TAVVLCVFVK HHDTPIVKAN NRSLSYLLLM SLMFCFLCSF FFIGLPNRAI CVLQQITFGI
VFTVALSTVL AKTVTVVLAF KVTDPGRRLR NFLVSGTPNY IIPICSLLQC VLCAIWLAVS
PPFVDIDEHT LHGHIIIVCN KGSVTAFYCI LGYLACLALG SFSVAFLAKN LPDAFNEAKF
LTFSMLVFCS VWVTFLPVYH STKGKHMVAV EIFSILASSA GILGCIFVPK IYIILTRPER
NSTQKIREKS YF
//
