ID L7N2E9_MOUSE Unreviewed; 908 AA.
AC L7N2E9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Vomeronasal 2, receptor 2 {ECO:0000313|Ensembl:ENSMUSP00000135110.2};
GN Name=Vmn2r2 {ECO:0000313|Ensembl:ENSMUSP00000135110.2,
GN ECO:0000313|MGI:MGI:3757666};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000135110.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000135110.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135110.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000135110.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000135110.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_006500873.1; XM_006500810.2.
DR AlphaFoldDB; L7N2E9; -.
DR SMR; L7N2E9; -.
DR STRING; 10090.ENSMUSP00000077109; -.
DR PaxDb; 10090-ENSMUSP00000135110; -.
DR Ensembl; ENSMUST00000177151.9; ENSMUSP00000135110.2; ENSMUSG00000043897.14.
DR AGR; MGI:3757666; -.
DR MGI; MGI:3757666; Vmn2r2.
DR VEuPathDB; HostDB:ENSMUSG00000043897; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000160473; -.
DR HOGENOM; CLU_005389_1_0_1; -.
DR InParanoid; L7N2E9; -.
DR OMA; PKRENAD; -.
DR OrthoDB; 5308018at2759; -.
DR PhylomeDB; L7N2E9; -.
DR BioGRID-ORCS; 100125586; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Vmn2r2; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; L7N2E9; Protein.
DR Bgee; ENSMUSG00000043897; Expressed in mesodermal cell in embryo and 2 other cell types or tissues.
DR ExpressionAtlas; L7N2E9; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15280; 7tmC_V2R-like; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF530; VOMERONASAL 2 RECEPTOR 128-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..908
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003982280"
FT TRANSMEM 615..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 616..871
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 908 AA; 101697 MW; 4A3433412FF959A5 CRC64;
MASRKMCLIL GLTVFLWVEL HAQENVTCKL LRKFNLSGYV EAENHSMVIG GLFPIHSRTI
PTNNSDEVPV SAMCEGFNFR GFRWMKTMIH TIKEINERKD ILPNHTLGYQ IFDTCFSVSK
AMETALAFLT GQEENKPNFR NSTGKYLVGI IGAGGSSLSV AAARILGLYY IPQVGYTSSC
AVLSDTFQFP SFYRSTPSDK FQSEGMVSLI QHFGWVWVGT IASDDDYGKY GVKSLRERME
FVNLCVAFSE TIPKVYSNEK MQKAIKAIKS STAKVIVLFS TDIDLGPFVL EVIHHNITDR
TWIASEAWIT SALIAKPEYF PYFGGTIGFA IPRSVIPGLK EFLYDVHPSK NPNDVLTIEF
WQTAFNCTWP NSSVPYNVDH RVNMTGKEDR LYDMSDQLCT GEEKLEDLKN TYLDTSQLRI
TNNVKQAVYL MAYALDRLST CDLLEEQRND TACSHIPDFE PKELMTYFKK LKIITHDGAE
IELDLNGDVG KGYYDILNWH MGNTGEITFV KVGEYKYTST KSELVLPKNS SLFWNTESSM
LPESVCTKLC APGTRRGIRQ GQPVCCFNCI PCADGYVSEK SGQRECDPCG EDDWSNAEKS
KCVPKLVEFL AYGEALGFTL VILSIFGALV VLAVTVVYVI HRHTPLVKAN DRELSFLIQM
SLVITVLSSL LFIGKPCNWS CMARQITLAL GFCLCLSSIL GKTISLFFAY RISVSKTRLI
SMHPIFRKLI VLVCVVGEIG VCAAYLVLEP PRMFKNIEIQ NVKIIFECNE GSVEFLCSIF
GFDVLLALLC FLTTFVARQL PDNYYEGKCI TFGMLVFFIV WISFVPAYLS TKGKFKVAVE
IFAILASSYG LLGCLFLPKC FIILLRPKRN TDETVGGRVP TVDRSIQLTS ASVSSELNST
TVSTVLDE
//
