ID L7N2K9_XENTR Unreviewed; 876 AA.
AC L7N2K9; A0A5S6JZW5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=von Willebrand factor A domain containing 5A, gene 2 {ECO:0000313|Ensembl:ENSXETP00000005029, ECO:0000313|RefSeq:XP_031754570.1};
GN Name=vwa5a.2 {ECO:0000313|Ensembl:ENSXETP00000005029,
GN ECO:0000313|RefSeq:XP_031754570.1,
GN ECO:0000313|Xenbase:XB-GENE-5991892};
GN Synonyms=loh11cr2a {ECO:0000313|RefSeq:XP_031754570.1}, vwa5a
GN {ECO:0000313|Xenbase:XB-GENE-5991892};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000005029};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000005029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000005029};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000005029}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031754570.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031754570.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031754570.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_031754570.1; XM_031898710.1.
DR PaxDb; 8364-ENSXETP00000040314; -.
DR Ensembl; ENSXETT00000005029; ENSXETP00000005029; ENSXETG00000002363.
DR AGR; Xenbase:XB-GENE-5991892; -.
DR AGR; Xenbase:XB-GENE-961538; -.
DR Xenbase; XB-GENE-5991892; vwa5a.2.
DR eggNOG; ENOG502QRPK; Eukaryota.
DR OrthoDB; 1377744at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000002363; Expressed in neurula embryo and 12 other cell types or tissues.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR45737; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR45737:SF8; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 2..132
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 280..468
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 876 AA; 94819 MW; 838B7DF1DE3DD507 CRC64;
MDSCCGLIIS CSKVPVPLRG ISVEVQVKGF VADVCATLRY KNTEEKPIEA IFVFPLDQDS
AVYSFEATVE GKTIVAELQE REQAHKTYDE AISQGQEAFL LEEDKSSGDI FSCSVGNLPP
GQEAEVKLSF VRELPVESDG AVRFVLPTVL NPRYTPKDHD MSVTAAIPRL PADKIPYSLA
LNAHFQSVYG ISKIESNCQL EPIQYTDGDK LSAKVSLAQG HKFDKDVELL AYYLQANTPS
AMVEAGLPDA VEGSIMADPV VMLNFYPNIP ETKEKANSGE FIFLMDRSGS MMDNMSSEQN
APRRIDSAKE TLILLLKSLP LGCYFNIFSF GSEFSSIFSE STAYTQESMA EAVKLVNQMD
ADMGGTEILE PLKRIYKTAG RPAHPRQLFV FTDGEVGNTK FVIDEVRRNA HNHRCFTFGI
GDGASTALIK GLARAASGTF EFITGKERMQ PKVLQTLKCS LQPMVKDITL TWILPPGVEA
KLLSGTPTAI FQGQKSIVYA QLKGKVEQGT EGQVSLAYSF KDEMVANVLR FTLKLTQSER
PTMHRLAAKV VISNLIGGEN LEEKSEEVQK QIVETSVQSG VISPLTAYVA VNKETKNPVK
GPPVQRSIPL YGAPVAMACC MPMPRMMPGG PPRALACSMA APGGYKPQIA VCHFPAPTPM
PAMPLLPTPE LADPTSGPAE GLSEPEIAVC YWSDSATVSD GATSAPAEGS PEPKVEVCYW
PDPASVSDGA TSAPAEGSPE PKVEVCYWPD PASVSDGATS APAEAKAERA LFQLISLQNA
DGSWNLNSEL ASVFEMSEEA LKEKIPDPSV DASLWATVLA VMWLHAARPQ QRDEWELLED
KALDWIKAKA APSLSECVRA GNQLLNCSVG SEVFGL
//
