ID L7N472_MOUSE Unreviewed; 848 AA.
AC L7N472;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Vomeronasal 2, receptor 8 {ECO:0000313|Ensembl:ENSMUSP00000126953.2};
GN Name=Vmn2r8 {ECO:0000313|Ensembl:ENSMUSP00000126953.2,
GN ECO:0000313|MGI:MGI:3642986};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000126953.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000126953.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126953.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000126953.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000126953.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001098090.1; NM_001104620.1.
DR AlphaFoldDB; L7N472; -.
DR SMR; L7N472; -.
DR STRING; 10090.ENSMUSP00000126953; -.
DR iPTMnet; L7N472; -.
DR PhosphoSitePlus; L7N472; -.
DR PaxDb; 10090-ENSMUSP00000126953; -.
DR Ensembl; ENSMUST00000172140.3; ENSMUSP00000126953.2; ENSMUSG00000090961.3.
DR GeneID; 627479; -.
DR KEGG; mmu:627479; -.
DR UCSC; uc009vdf.1; mouse.
DR AGR; MGI:3642986; -.
DR CTD; 627479; -.
DR MGI; MGI:3642986; Vmn2r8.
DR VEuPathDB; HostDB:ENSMUSG00000090961; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000183069; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR InParanoid; L7N472; -.
DR OMA; RHTESHI; -.
DR OrthoDB; 4188279at2759; -.
DR PhylomeDB; L7N472; -.
DR BioGRID-ORCS; 627479; 4 hits in 40 CRISPR screens.
DR ChiTaRS; Vmn2r8; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; L7N472; Protein.
DR Bgee; ENSMUSG00000090961; Expressed in pancreas.
DR ExpressionAtlas; L7N472; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF411; VOMERONASAL 2, RECEPTOR 10-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..848
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003982456"
FT TRANSMEM 582..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..846
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 848 AA; 97191 MW; 851B6F1A3F37895B CRC64;
MKKLRTFTIS FLLLKFSLIL CHVTDPICFW RIKNNEENDG DLRSDCNFLL WTDYESTEFN
FYNIVDFRIP ARRYEYFLVL FFATDEINKN PDLLPNMSLI VWLLSGQCGD EWSVLHKNYS
QENINVKFIN YDCLSPACYI DLTGPSWKTS LKMSIQSRTP KVFFGPFNPD LRDHDQFPFV
HQVATKDTYL SHAMVSLMHH FRWMWIGLVI SDDDQGIQFL SDLREEMQRH GICLAFVNMI
PENMQIYMTR ATIYDKQIME STAKVVIIYG EMNSTLEVSF RRWEDLGVRR IWITTSQWDV
ITNKNDFSLD FFHGTVTFEH HHSEIAKFKN FMKTMNTDKY PVNISQSIVG WNYFNCSTSM
NSFSKMDHLT FNNTLEWTAL HNFDMVLSEE GYNLYNAVYA VAHTYHELIL LQVESQQTEV
PKGIFTDCQQ VASMLKSRIF TNPIGELVNM KHRENQCADY DIFIIWNFPQ GLGLKVKIGS
YLHCFSQSQQ LHISEDLEWA TGGTSVPSSL CSVTCTAGFR KIHQNETADC CFDCDQCPEN
EVSNETADME QCVRCPDDKY ANLEKTHCLQ RAVSFLAYED PWGMALGCMA LFLSALTVLV
LVTFVKYKDT PIVKANNRIL SYILLISLVF CFLCSLLFIG HPNQATCILQ QTTFGVFFTV
AISTVLAKTI TVLMAFKLTT PGRRMRGMLA SGAPNLVIPI CTLIQLFLCG IWLVTSPPFI
DRETQSEYGK TIIICNKGSV IAFHFVLGYL GSLALGSFTV AFLARNLPDR FNEAKFLTFS
MLVFCSVWIT FLPVYHSTRG TVMVVVEVFS ILASSAGLLG CIFLPKCCVI LVRLDSNFLQ
KYKDKLPS
//
