ID   L7UBP7_MYXSD            Unreviewed;       420 AA.
AC   L7UBP7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:AGC44997.1};
GN   OrderedLocusNames=MYSTI_03691 {ECO:0000313|EMBL:AGC44997.1};
OS   Myxococcus stipitatus (strain DSM 14675 / JCM 12634 / Mx s8).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=1278073 {ECO:0000313|EMBL:AGC44997.1, ECO:0000313|Proteomes:UP000011131};
RN   [1] {ECO:0000313|EMBL:AGC44997.1, ECO:0000313|Proteomes:UP000011131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14675 / JCM 12634 / Mx s8
RC   {ECO:0000313|Proteomes:UP000011131};
RX   PubMed=23516218; DOI=10.1128/genomeA.00100-13;
RA   Huntley S., Kneip S., Treuner-Lange A., Sogaard-Andersen L.;
RT   "Complete genome sequence of Myxococcus stipitatus strain DSM 14675, a
RT   fruiting myxobacterium.";
RL   Genome Announc. 1:E0010013-E0010013(2013).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
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DR   EMBL; CP004025; AGC44997.1; -; Genomic_DNA.
DR   RefSeq; WP_015349257.1; NC_020126.1.
DR   AlphaFoldDB; L7UBP7; -.
DR   STRING; 1278073.MYSTI_03691; -.
DR   KEGG; msd:MYSTI_03691; -.
DR   PATRIC; fig|1278073.3.peg.3753; -.
DR   eggNOG; COG3425; Bacteria.
DR   HOGENOM; CLU_008065_3_2_7; -.
DR   OrthoDB; 9769523at2; -.
DR   Proteomes; UP000011131; Chromosome.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 2.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
FT   DOMAIN          3..169
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          176..269
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
FT   DOMAIN          288..390
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   420 AA;  44737 MW;  14F5C47AD9E4C726 CRC64;
     MKKRVGIEAL AVAVPSRYVD IEDLARARGV DPAKFTSGLG AREMAVTDPG EDTVALAATA
     AARLIQQQGV DTSRIGMLVV GTETGIDHSK PVASHVQGLL KLPRTMRTFD TQHACYGGTA
     GLMAATEWIA SGAGAGKVAI VICSDIARYG LNTAGEPTQG GGAVALLVSE QPDLLALDVG
     LNGTCTMDVY DFWRPVGRRE ALVDGHYSIN CYLEALSGAY RGWREKALEH GLVRWSGTMP
     GEQLARIAYH VPFCKMARKA HTQLRLCDLE DAVGPGPGTP EAREEVAKSS ASYDAQVATS
     LGLNSRIGNV YTASLYLALA GLLQREGAQL ASQRIGLLSY GSGCMAEFYS GVVGEKAAER
     MARADLEGVL ARRERVSIEE YERLMKLPSD SPEAKAPAPG TFRLAEIRDH KRIYVEGGAA
//