ID L7UFH6_MYXSD Unreviewed; 462 AA.
AC L7UFH6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Alkaline serine exoprotease A {ECO:0000313|EMBL:AGC47696.1};
GN OrderedLocusNames=MYSTI_06423 {ECO:0000313|EMBL:AGC47696.1};
OS Myxococcus stipitatus (strain DSM 14675 / JCM 12634 / Mx s8).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=1278073 {ECO:0000313|EMBL:AGC47696.1, ECO:0000313|Proteomes:UP000011131};
RN [1] {ECO:0000313|EMBL:AGC47696.1, ECO:0000313|Proteomes:UP000011131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14675 / JCM 12634 / Mx s8
RC {ECO:0000313|Proteomes:UP000011131};
RX PubMed=23516218; DOI=10.1128/genomeA.00100-13;
RA Huntley S., Kneip S., Treuner-Lange A., Sogaard-Andersen L.;
RT "Complete genome sequence of Myxococcus stipitatus strain DSM 14675, a
RT fruiting myxobacterium.";
RL Genome Announc. 1:E0010013-E0010013(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP004025; AGC47696.1; -; Genomic_DNA.
DR RefSeq; WP_015351950.1; NC_020126.1.
DR AlphaFoldDB; L7UFH6; -.
DR STRING; 1278073.MYSTI_06423; -.
DR KEGG; msd:MYSTI_06423; -.
DR PATRIC; fig|1278073.3.peg.6521; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_011263_1_7_7; -.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000011131; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..462
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003984411"
FT DOMAIN 426..462
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT ACT_SITE 175
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 208
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 363
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 462 AA; 48230 MW; 9C45E60B1D65353A CRC64;
MRPHLSLAHR ARAVAFRTLS LLGALALGGS ACGERPSSGE PAAAAVDTVK LARLTRAPES
LRVPGEYVVV FAQGLSGGAL TAAADTITRA GGTNTLLHRY SLIPGFTARL DDAQLDRLRR
DPGVAYIEEN QHVFLKSAVP SPSDGIDRVD QRQGRDGQYN DYENTGAGVH VYVLDTGLNT
EHSEFTGRVG SSESFVFDGF GVEDCHGHGT HVASTAVGTQ YGMAKQATLH PVRILNCIGR
ATWGTIIAGL EFVRMDCPRQ DGPCVANLSL SGEFFQPVNQ AAAALVDAGI PVVVAAGNSN
IDACLESPGS EPKVINVGAV DDNDKRALFS NWGTCVDLFA PGVSILGAWA GDAVATNIDD
GTSMAAPHVT GAVAQYLESH RTATPAQVTV NLKGAATLGC VDDLMGSPNS LLFSDLSQGN
YLCVADPNSC KGLCGGAATG CFCDPTCLEF NDCCPDFQQV CQ
//
